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1.
Am J Med Sci ; 366(4): 316-320, 2023 10.
Article in English | MEDLINE | ID: mdl-37473959

ABSTRACT

Bing-Neel syndrome, a rare neurological complication of Waldenström macroglobulinemia, is caused by the direct infiltration of malignant lymphoplasmacytic cells into the central nervous system. We report a patient who presented with back pain, weakness, lower extremity numbness, and gait disturbance accompanied by immunoglobulin M paraproteinemia and lymphoplasmacytic lymphoma in the bone marrow. Thoracic and lumbar magnetic resonance imaging revealed a long paravertebral mass around the spinal column, but the direct infiltration could not be proven. The patient was diagnosed with possible Bing-Neel syndrome and managed with bendamustine and rituximab. After chemotherapy, the patient's neurological and radiological findings improved. Magnetic resonance imaging should be considered when the Bing-Neel syndrome diagnosis is unclear.


Subject(s)
Brain Diseases , Waldenstrom Macroglobulinemia , Humans , Waldenstrom Macroglobulinemia/complications , Waldenstrom Macroglobulinemia/drug therapy , Waldenstrom Macroglobulinemia/diagnosis , Syndrome , Rituximab/therapeutic use , Magnetic Resonance Imaging
2.
Case Rep Oncol ; 13(2): 1020-1025, 2020.
Article in English | MEDLINE | ID: mdl-32999666

ABSTRACT

Although tyrosine kinase inhibitors markedly improve the clinical outcome of chronic myeloid leukemia (CML), blast crisis in CML (CML-BC) still has a poor prognosis. Many chromosomal abnormalities have been reported in CML-BC and may contribute to therapeutic resistance, disease progression, and prognosis. Herein, we report a rare chromosome abnormality with der(16)t(1;16)(q12;q11.2) in CML-BC. It has been demonstrated that this chromosomal abnormality is associated with disease progression and poor prognosis in other malignancies, such as Ewing sarcoma. A 70-year-old man with CML who had been treated with imatinib and dasatinib was admitted to our hospital after complaining for several weeks of fatigue and dyspnea and diagnosed with CML-BC. His tumor cells presented additional chromosomal abnormality with der(16)t(1;16)(q12;q11.2), which has never been reported in CML cases. We successfully treated him using cytotoxic agents combined with ponatinib, and this chromosome abnormality was detected via G-banding. Our patient has lived for over 8 months without any progression with ponatinib treatment alone. Although the biological function of this chromosomal abnormality remains unclear, the satellite DNA of 1q12, which induces genomic instability in other malignancies, and the loss of 16q may contribute to the disease progression of CML in this case. In conclusion, this paper is the first to report on the case of CML-BC with der(16)t(1;16)(q12;q11.2).

3.
Intern Med ; 59(7): 997-1000, 2020 Apr 01.
Article in English | MEDLINE | ID: mdl-31839656

ABSTRACT

TAFRO syndrome is rare, and its pathophysiology remains unclear. We herein report the case of a 66-year-old man who presented at our emergency department with epigastric pain. Contrast-enhanced computed tomography (CT) showed high-density retroperitoneal panniculus with contrast enhancement. He was treated initially with a protease inhibitor and hydration, to little effect. Anasarca, thrombocytopenia, and renal dysfunction developed gradually, and TAFRO syndrome was diagnosed. He was treated successfully with prednisolone and cyclophosphamide, and subsequent CT findings showed improvement. Abnormal CT findings of the retroperitoneum may indicate the early stages of TAFRO syndrome before the presentation of typical ascites.


Subject(s)
Castleman Disease/diagnosis , Castleman Disease/physiopathology , Cyclophosphamide/therapeutic use , Edema/drug therapy , Prednisolone/therapeutic use , Thrombocytopenia/drug therapy , Thrombocytopenia/etiology , Aged , Antirheumatic Agents , Edema/diagnosis , Glucocorticoids/therapeutic use , Humans , Male , Thrombocytopenia/diagnosis , Treatment Outcome
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