1.
Farmaco Sci
; 35(8): 691-7, 1980 Aug.
Article
in English
| MEDLINE
| ID: mdl-7450053
ABSTRACT
Clozapine, a neuroleptic drug isostere of the phenothiazines, at a dose of 10(-3) M decreased the oxygen consumption of rat brain slices and homogenates. However, this effect was not potentiated when brain slices were incubated with 100 mM potassium or in a calcium-free medium, the uncoupling of brain mitochondrial oxidative phosphorylation by 10(-3) M clozapine can also be rulled out.
Subject(s)
Brain/drug effects , Clozapine/pharmacology , Dibenzazepines/pharmacology , Glucose/metabolism , Oxidative Phosphorylation/drug effects , Oxygen Consumption/drug effects , Animals , Brain/metabolism , Brain/ultrastructure , In Vitro Techniques , Male , Mitochondria/metabolism , Rats
2.
Arch Farmacol Toxicol
; 5(3): 290-2, 1979 Dec.
Article
in Spanish
| MEDLINE
| ID: mdl-546358
3.
Farmaco Sci
; 32(9): 672-7, 1977 Sep.
Article
in English
| MEDLINE
| ID: mdl-20331
ABSTRACT
Dibenzepin hydrochloride (10(-3) M) decreases the oxygen uptake of whole brain homogenates and uncouples brain mitochondrial oxidative phosphorylation. At the same concentration this drug inhibits oxygen uptake of rat brain slices when calcium is absent in the incubation or then contains an excess of potassium.
