Quiste óseo aneurismático mandibular de tipo sólido / Mandibular solid aneurysmal bone cyst

El quiste óseo aneurismático sólido es una lesión ósea benigna muy infrecuente de la que no existe consenso en relación a su origen etiopatogénico. Presenta características clínicas, radiológicas e histológicas inespecíficas, por lo que los estudios ultraestructurales son fundamentales para su diagnóstico y clasificación. El diagnóstico diferencial es extenso e incluye múltiples lesiones óseas como el granuloma reparativo de células gigantes e incluso tumores malignos como el osteosarcoma. El tratamiento de elección es la cirugía conservadora. La recidiva se debe fundamentalmente a la extirpación incompleta(AU)

Solid aneurysmal bone cyst is a rare benign bone lesion for which no consensus exists regarding its origin. It has nonspecific clinical, radiological and histological features so ultrastructural studies are essential for diagnosis and classification. The differential diagnosis is extensive and includes a variety of bone lesions, such as giant cell reparative granuloma, and even malignant tumors like osteosarcoma. The treatment of choice is conservative surgery. Recurrence is due mainly to incomplete resection(AU)

Tumor de Warthin gigante / Giant Warthin tumour

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Mandibular solitary plasmocytoma of the jaw: A case report

Plasma cell tumors are lymphoid neoplasms with an uncontrolled proliferation of B cells. These are divided intolocalized forms (solitary bone plasmocytoma -SBP- and extramedullary plasmocytoma -EP-) and disseminatedforms (multiple myeloma–MM-). The SBP is a rare and controversial disease. The aim of this article is the analysisof this entity based on the presentation of a 64-year-old man without previous medical history, with a mass in theleft mandibular angle extending to the parotid region on the same side. The panoramic radiography, computedtomography and magnetic resonance imaging showed an osteolytic lesion 6.5 x 5 x 6.7 cm in the mandibularangle with infiltration of the masticator space and left parotid region. The normality of the extension study, andhistopathological examination confirmed the diagnosis of SBP. The patient received treatment with radiotherapywith good outcome (AU)

Unilateral submandibular gland aplasia with ipsilateral sublingualgland hypertrophy presenting as a neck mass

The congenital absence of the major salivary glands is a very infrequent disorder, in which several glands are usuallyinvolved at the same time. Sometimes this disorder can be associated with other developmental anomalies.The unilateral aplasia of the submandibular gland is an extremely rare finding with only 14 cases reported in theliterature. Clinically, this kind of patients may complain of dryness of the mouth, difficulties in chewing and swallowing,severe periodontal disease or multiple caries, but usually they follow an asymptomatic course. Salivarygland aplasia can be diagnosed with a large variety of imaging techniques, which include computer tomography(CT), magnetic resonance imaging (MR), ultrasonography (US), sialography, or scintigraphy. In this paper wereport a case of a patient referred to our department with a long term and progressive growing neck mass, who hasan unilateral submandibular gland aplasia associated to an ipsilateral hypertrophy of the sublingual gland (AU)

Unilateral submandibular gland aplasia with ipsilateral sublingual gland hypertrophy presenting as a neck mass.

The congenital absence of the major salivary glands is a very infrequent disorder, in which several glands are usually involved at the same time. Sometimes this disorder can be associated with other developmental anomalies. The unilateral aplasia of the submandibular gland is an extremely rare finding with only 14 cases reported in the literature. Clinically, this kind of patients may complain of dryness of the mouth, difficulties in chewing and swallowing, severe periodontal disease or multiple caries, but usually they follow an asymptomatic course. Salivary gland aplasia can be diagnosed with a large variety of imaging techniques, which include computer tomography (CT), magnetic resonance imaging (MR), ultrasonography (US), sialography, or scintigraphy. In this paper we report a case of a patient referred to our department with a long term and progressive growing neck mass, who has an unilateral submandibular gland aplasia associated to an ipsilateral hypertrophy of the sublingual gland.

Carcinoma ex adenoma parotídeo: a propósito de un caso / No disponible

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Hemangioma de seno maxilar / Maxillary sinus haemangioma

Paciente de 71 años de edad, sin antecedentes clínicos de interés, valorada por una masa en el hemimaxilar superior izquierdo de 6 meses de evolución. La tomografía computerizada y la resonancia magnética mostraron una lesión de 7,7×6,9×4,7cm en el seno maxilar izquierdo. La biopsia escisional confirmó el diagnóstico de hemangioma (AU)

We report the case of 71-year-old woman with no prior history who had a left maxillary mass for 6 months. Axial Tomography and Nuclear Magnetic Resonance revealed a lesion of 7.7×6.9×4.7cm in the left maxillary sinus. Excisional biopsy confirmed the diagnosis of haemangioma (AU)

[Maxillary sinus haemangioma]. / Hemangioma de seno maxilar.

We report the case of 71-year-old woman with no prior history who had a left maxillary mass for 6 months. Axial Tomography and Nuclear Magnetic Resonance revealed a lesion of 7.7x6.9x4.7cm in the left maxillary sinus. Excisional biopsy confirmed the diagnosis of haemangioma.

Life-threatening pseudoaneurysm of the facial artery after dental extraction: successful treatment with emergent endovascular embolization.

Vascular complications after third molar extraction are very rare but may cause a life-threatening situation. The case presented is that of a 25-year-old male who appeared at our emergency department with severe dyspnea and increasing swelling of the left submandibular area 3 days after dental extraction. CT angiography and digital subtraction angiography demonstrated a pseudoaneurysm of the facial artery. Subsequent emergent endovascular embolization with n-Butyl-2-Cyanoacrylate was performed and the patient had a rapid satisfactory resolution.

Randomized phase II study of cisplatin and 5-FU continuous infusion (PF) versus cisplatin, UFT and vinorelbine (UFTVP) as induction chemotherapy in locally advanced squamous cell head and neck cancer (LA-SCHNC).

OBJECTIVES: We conducted a multicentric randomized phase II trial comparing 5-FU continuous infusion (PF) and cisplatin, UFT and vinorelbine (UFTVP) as induction chemotherapy (IC) in locally advanced squamous cell head and neck cancer (LA-SCHNC). Primary objective was complete response (CR) to IC and overall survival (OS) was a secondary objective. MATERIALS AND METHODS: PF: cisplatin 100 mg/m(2) i.v. Day 1 (D1) and 5-FU 1,000 mg/m(2) per day i.v. continous infusion D1-D5, every 21 days. UFTVP: cisplatin 100 mg/m(2) i.v. D1; UFT 200 mg/m(2) per day p.o. D1-D21 and vinorelbine 25 mg/m(2) i.v. D1 and D8, every 21 days. Four IC courses were planned in both arms. RESULTS: A total of 206 patients (pts) were included (PF/UFTVP: 99/107): oral cavity: 8%/10%, oropharynx: 20%/25%, hypopharynx: 17%/14%, larynx: 54%/50%. Stage (TNM, 2002): III: 41%/35%, IVA: 23%/27%, IVB: 35%/38%. Complete response to IC: PF:36%/UFTVP:31% (P: no significative (NS)). G 3-4 toxicity (PF/UFTVP): neutropenia: 52%/72%; febrile neutropenia: 3%/20% (P < 0.001); anaemia:1%/14% (P < 0.001); trombocytopenia: 5%/0% (P = 0.02); mucositis: 15%/7% (P < 0.001). Deaths during IC: 2(2%)/3(3%). IC with UFTVP was associated with a favourable OS in the Cox analysis (actuarial 5 year OS: 49% vs. 34%; HR: 0.67, 95% CI: 0.47-0.95, P: 0.03). CONCLUSIONS: Although clinical response is equal in both arms, overall survival (Cox) is better in the UFTVP arm. Febrile neutropenia and anaemia were more frequent with UFTVP while mucositis and trombocytopenia were more severe with PF.

Estudio inmunohistoquímico del carcinoma epidermoide de labio / Epidermoid carcinoma of the lip: An immunohistochemical study

Objetivos: Determinar la sobreexpresión de las proteínas cerb-B2, p53, bcl-2, Ki67 y CD44varV6 y establecer su valorpronóstico en el carcinoma epidermoide de labio.Diseño del estudio: Estudio inmunohistoquímico de las proteínasp53, c-erb-B2, bcl-2, ki67 y CD44varV6 en 79 carcinomasepidermoides de labio diagnosticados y tratados a lo largo deun periodo de 20 años. Los datos obtenidos fueron sometidosa análisis estadístico uni y multivariante.Resultados: La inmunotinción fue positiva en el 75% de los casospara la proteína c-erb-B2, en el 70,6% para la proteína p 53, enel 3,8% para la proteína bcl-2 y en el 89,9% para la molécula deadhesión cd44varV6. La expresión proteica de ki67 osciló entreun mínimo de 0% y un máximo de 6,29%. Los factores inmunohistoquímicosanalizados no presentaron valor pronóstico enel carcinoma epidermoide de labio, y solamente los pacientesafectados por este tipo de tumores que expresaban la moléculade adhesión CD44varV6 se asociaron de forma significativa conuna mayor supervivencia mediante el análisis de Kaplan-Meier.Conclusiones: Las técnicas inmunohistoquímicas analizadaspara el estudio anatomopatológico del carcinoma epidermoidede labio no deberían realizarse rutinariamente, dado su mayorcoste y su menor utilidad en la práctica clínica diaria

Objectives: To determine the expression of the c-erb-B2, p53,bcl-2, Ki67 and CD44varV6 proteins, and to establish theirprognostic value in epidermoid carcinoma of the lip.Study design: Immunohistochemical study of the c-erb-B2,p53, bcl-2, Ki67 and CD44varV6 proteins in 79 epidermoidcarcinomas of the lip, diagnosed and treated over a period of 20years. The data obtained were subjected to uni- and multi-variatestatistical analyses.Results: Immunostaining was positive in 75% of cases for c-erb-B2 protein, in 70.6% for p53 protein, in 3.8% for bcl-2 proteinand in 89.9% for adhesion molecule CD44varV6. Ki67 proteinexpression varied between a minimum of 0% and a maximum of6.29%. Most immunohistochemical factors analyzed presentedno prognostic value for epidermoid carcinoma of the lip. Onlythose patients affected by this type of tumor that expressed theadhesion molecule CD44varV6 were significantly associatedwith a greater survival calculated by means of Kaplan-Meieranalysis.Conclusions: The immunohistochemical techniques analyzedfor the anatomicopathological study of epidermoid carcinomaof the lip should not routinely be used due to their high cost andlow utility in daily clinical practice

Carcinoma oral de células escamosas. Parámetros citométricos de interés pronóstico / Oral squamous cell carcinoma. Cytometric parameters of prognostic interest

Objetivos: el presente estudio se realizó para encontrar posiblesfactores pronósticos del Carcinoma oral de células escamosaspuesto que es una enfermedad frecuente ( 3 – 4 % de los tumoresmalignos ) que origina una gran morbilidad y mortalidad y quejustifica cualquier intento que trate de aportar algo para conocermejor esta patología. Diseño del estudio: hemos realizadoun estudio sobre 81 carcinomas orales de células escamosasextraídos del archivo del Hospital Universitario Marqués deValdecilla ( Santander ) , tratados con el mismo procedimiento, de los cuales en 67 de ellos se realizó citometría de flujo.Resultados: No hemos encontrado diferencias estadísticamentesignificativas entre el índice de proliferación celular y el índicemitótico , la ploidía y la fase S. Así mismo ninguna de lasvariables citométricas estudiadas ha presentado relación conla aparición de recidiva loco-regional , metástasis a distanciani con la supervivencia.Conclusiones: no podemos utilizar éstas variables como factor pronósticoen el carcinoma de células escamosas de la cavidad oral

Objectives: the present study was made in order to find possibleprognostic factors in oral squamous cell carcinoma, given thatit is a frequent disease (3-4% of all malignant tumors) and isthe cause of a high morbidity and mortality which justifies anyattempt to contribute something towards the understanding ofthis pathology.Study design: 81 oral squamous cell carcinomas, treated with thesame procedure, and retrieved from the archive of the HospitalUniversitario Marqués de Valdecilla (Santander) were studied.Flow cytometry was carried out on 67 of the samples.Results: no statistically significant differences were foundbetween the cellular proliferative index and the mitotic index,ploidy and the S-phase factor. Likewise, none of the cytometricvariables studied presented any association with the appearanceof local relapse, distant metastases or survival.Conclusions: these variables cannot be used as a prognosticfactors in squamous cell carcinomas of the oral cavity

Oral squamous cell carcinoma. Cytometric parameters of prognostic interest.

OBJECTIVES: The present study was made in order to find possible prognostic factors in oral squamous cell carcinoma, given that it is a frequent disease (3-4% of all malignant tumors) and is the cause of a high morbidity and mortality which justifies any attempt to contribute something towards the understanding of this pathology. STUDY DESIGN: 81 oral squamous cell carcinomas, treated with the same procedure, and retrieved from the archive of the Hospital Universitario Marqués de Valdecilla (Santander) were studied. Flow cytometry was carried out on 67 of the samples. RESULTS: No statistically significant differences were found between the cellular proliferative index and the mitotic index, ploidy and the S-phase factor. Likewise, none of the cytometric variables studied presented any association with the appearance of local relapse, distant metastases or survival. CONCLUSIONS: These variables cannot be used as a prognostic factors in squamous cell carcinomas of the oral cavity.

Epidermoid carcinoma of the lip: an immunohistochemical study.

OBJECTIVES: To determine the expression of the c-erb-B2, p53, bcl-2, Ki67 and CD44varV6 proteins, and to establish their prognostic value in epidermoid carcinoma of the lip. STUDY DESIGN: Immunohistochemical study of the c-erb-B2, p53, bcl-2, Ki67 and CD44varV6 proteins in 79 epidermoid carcinomas of the lip, diagnosed and treated over a period of 20 years. The data obtained were subjected to uni- and multi-variate statistical analyses. RESULTS: Immunostaining was positive in 75% of cases for c-erb-B2 protein, in 70.6% for p53 protein, in 3.8% for bcl-2 protein and in 89.9% for adhesion molecule CD44varV6. Ki67 protein expression varied between a minimum of 0% and a maximum of 6.29%. Most immunohistochemical factors analyzed presented no prognostic value for epidermoid carcinoma of the lip. Only those patients affected by this type of tumor that expressed the adhesion molecule CD44varV6 were significantly associated with a greater survival calculated by means of Kaplan-Meier analysis. CONCLUSIONS: The immunohistochemical techniques analyzed for the anatomicopathological study of epidermoid carcinoma of the lip should not routinely be used due to their high cost and low utility in daily clinical practice.

Cóndilo bífido: a propósito de un caso / Bifid condyle: case report

En este artículo, a propósito de un caso clínico, se presenta elcóndilo bífido como una rara alteración mandibular con muchasincógnitas. Su diagnóstico suele ser un hallazgo casual en radiografíaspanorámicas de rutina. El número de casos relatados enliteratura ha experimentado en los últimos años un crecimientodebido al aumento de pruebas radiológicas que se realizan. Sediscute sobre las diferentes teorías existentes con respecto a laetiología de este proceso. En lo referente a la relevancia clínicadel cóndilo bífido señalamos que la gran mayoría son asintomáticos.Es importante realizar un buen diagnóstico diferencialde éste proceso con otras lesiones que producen alteracionesmorfológicas condilares, la prueba de elección es la tomografíacomputerizada. El tratamiento conservador suele ser efectivo enlos casos con clínica de disfunción articular leve, la cirugía tansólo suele indicarse en casos de anquilosis condilar, normalmenteéstos casos son secundarios a traumatismos

The double headed mandible condyle is a rare alteration that isfrequently diagnosticated as an incidental finding in a panoramicradiograph. The different theories about its etiology areexplained in this article. Symptoms described with bifid condylesvary from case to case, but in most instances are absent.Computer tomography is the ideal imaging method to evaluatethe condyle morphology and to role out any degenerative processto achieve the differential diagnosis. Treatment is conservativefor symptomatic patients with TMJ disorders, surgical treatmentis described in literature in TMJ ankylosis that develops in bifidcondyles secondary to trauma

Bifid condyle: case report.

The double headed mandible condyle is a rare alteration that is frequently diagnosticated as an incidental finding in a panoramic radiograph. The different theories about its etiology are explained in this article. Symptoms described with bifid condyles vary from case to case, but in most instances are absent. Computer tomography is the ideal imaging method to evaluate the condyle morphology and to role out any degenerative process to achieve the differential diagnosis. Treatment is conservative for symptomatic patients with TMJ disorders, surgical treatment is described in literature in TMJ ankylosis that develops in bifid condyles secondary to trauma.