1.
Protein Pept Lett
; 17(3): 351-5, 2010 Mar.
Article
in English
| MEDLINE
| ID: mdl-19594435
ABSTRACT
Human cystathionine beta-synthase (CBS) is a pyridoxal 5'-phosphate (PLP) dependent hemoprotein, which catalyzes the condensation of serine and homocysteine. Our mutagenesis studies suggest that Arg-266 is important to sense structural changes in heme-binding site, and that Gln-222 as well as Tyr-223 are involved in interactions with substrates.