ABSTRACT
Cell membrane proteins of patients with hereditary spherocytosis, elliptocytosis and stomatocytosis were analyzed by SDS acrylamide gel electrophoresis. From 7 patients with hereditary spherocytosis only one can be supposed to have a reduction of a band with a molecular weight of about 80,000 daltons. 3 members of a family with hereditary elliptocytosis and 1 patient with hereditary stomatocytosis did not differ from the donors. The question of the nature of membrane defect in haemolytic anaemias could not be answered by the results obtained.
Subject(s)
Elliptocytosis, Hereditary/blood , Erythrocytes, Abnormal/analysis , Membrane Proteins/blood , Spherocytosis, Hereditary/blood , Erythrocyte Membrane/analysis , Humans , Membrane Proteins/geneticsABSTRACT
According to the immunological classification, plasmacytoma is assigned to the group of secretory immunocytomas. The designation "immunoproliferative hemoblastosis" implies certain peculiarities of immunological reactivity in its malignant transformation. The study deals with some of the more recent concepts on the immunochemical properties and morphological differentiation of plasmatic or plasmacytoma cells. Mention is also made of the results of some tests for evaluation of the function of T and B lymphocytes in patients suffering from a generalized plasmacytoma, during the course of chemotherapy.
