ABSTRACT
El seguimiento postoperatorio tiene un rol importante para la sobrevida del paciente después de la resección curativa del cáncer colorrectal. OBJETIVOS: Describir las características del seguimiento con tomografía por emisión de positrones (PET) integrado a tomografía axial computarizada (CT) (PET/CT) y su impacto en los sobrevivientes de cáncer colorrectal (CCR) posterior a la resección con intención curativa en un hospital universitario en la prefectura de Tochigi, Japón. MATERIAL Y MÉTODOS: Revisión consecutiva de las historias clínicas de 209 pacientes sometidos a estadificación prequirúrgica con PET/CT para la resección curativa de cáncer colorrectal entre abril de 2005 y marzo de 2008. La información de la evaluación postoperatoria se revisó hasta setiembre de 2008. RESULTADOS: De 209 pacientes que fueron estadificados preoperatoriamente por CCR, 207 (varones/mujeres = 125/82; edad promedio = 65,2 ± 11,4 años) fueron operados con intención curativa e incluidos en el presente estudio. La tasa de cumplimiento con los lineamientos de seguimiento de la Sociedad Japonesa para el Cáncer de Colon y Recto (JSCCR) fue del 53%. La sobrevida acumulada total al final del intervalo de estudio fue de 96.4%. La prueba más utilizada en el seguimiento postoperatorio del CCR fue el antígeno carcinoembrionario (CEA). La PET/CT fue la prueba que detectó más pacientes con lesiones recurrentes (n = 11; valor predictivo positivo = 23.4), entre ellos un paciente con lesión asintomática curable (metástasis a nódulo linfático inguinal), siendo la prueba con mayor efectividad (2.1%). No obstante, su elevado costo convierte a la PET/ CT en el procedimiento menos costo-efectivo. CONCLUSIONES: La utilización de PET/CT en el seguimiento posoperatorio tras resección curativa en CCR ha demostrado ser una alternativa individualizada y efectiva en el hallazgo de enfermedad asintomática curable. El estudio sistemático con CEA y CT como primera línea de despistaje y PET...
Postoperative surveillance has an important role in patient survival after curative resection of colorectal cancer. OBJECTIVES: To describe the characteristics of the follow-up with positron emission tomography(PET) / computed tomography (CT)(PET/CT) and its impact in colorectal cancer (CRC) survivors after curative resection in a university hospital in Tochigi Prefecture, Japan. MATERIALS AND METHODS: Consecutive review of patients hospital charts who underwent presurgical staging with PET/CT for curative resection of colorectal cancer between April 2005 and March 2008. The follow-up data of these patients was reviewed until September 2008. RESULTS: Of 209 patients presurgically staged for CRC, 207 (male/female = 125/82; mean age = 65.3 ± 11.3 years) underwent curative resection and were included in the present study. The compliance rate with the Japanese Society for Cancer of the Colon and Rectum (JSCCR) follow-up guidelines was 53%. The cumulative survival at the end of study interval was 96.4%. The test most commonly used in postoperative follow-up of CRC was the carcinoembryonic antigen (CEA). PET/CT was the test that detected more patients with recurrent lesions (n = 11, positive predictive value = 23.4), including one patient with an asymptomatic curable recurrence (inguinal lymph node metastasis), also being the most effective test (2.1%). However, its high cost makes it the less cost-effective. CONCLUSIONS: The use of PET/CT in the postoperative follow-up after curative resection in CRC has proven to be an individualized and effective alternative in the finding of asymptomatic disease curable. Systematic CEA tests with contrast-enhanced CT as a first line of screening and PET/CT as a second line may be an alternative follow up approach after curative resection for CRC.
Subject(s)
Humans , Male , Adolescent , Adult , Female , Child , Middle Aged , Colorectal Neoplasms , Postoperative Period , Survival , Positron-Emission TomographyABSTRACT
UNLABELLED: Postoperative surveillance has an important role in patient survival after curative resection of colorectal cancer. OBJECTIVES: To describe the characteristics of the follow-up with positron emission tomography (PET) / computed tomography (CT)(PET/CT) and its impact in colorectal cancer (CRC) survivors after curative resection in a university hospital in Tochigi Prefecture, Japan. MATERIALS AND METHODS: Consecutive review of patient's hospital charts who underwent presurgical staging with PET/CT for curative resection of colorectal cancer between April 2005 and March 2008. The follow-up data of these patients was reviewed until September 2008. RESULTS: Of 209 patients presurgically staged for CRC, 207 (male/female = 125/82; mean age = 65.3 ± 11.3 years) underwent curative resection and were included in the present study. The compliance rate with the Japanese Society for Cancer of the Colon and Rectum (JSCCR) follow-up guidelines was 53%. The cumulative survival at the end of study interval was 96.4%. The test most commonly used in postoperative follow-up of CRC was the carcinoembryonic antigen (CEA). PET/CT was the test that detected more patients with recurrent lesions (n = 11, positive predictive value = 23.4), including one patient with an asymptomatic curable recurrence (inguinal lymph node metastasis), also being the most effective test (2.1%). However, its high cost makes it the less cost-effective. CONCLUSIONS: The use of PET/CT in the postoperative follow-up after curative resection in CRC has proven to be an individualized and effective alternative in the finding of asymptomatic disease curable. Systematic CEA tests with contrast-enhanced CT as a first line of screening and PET/CT as a second line may be an alternative follow up approach after curative resection for CRC.