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1.
Bull Soc Pathol Exot ; 110(5): 291-296, 2017 Dec.
Article in French | MEDLINE | ID: mdl-29299882

ABSTRACT

Extremely widespread, the dengue is a reemerging infectious disease. In Burkina Faso, dengue is a reality that was little known. The aim of this study was to study epidemiology, diagnostic and outcomes of dengue patients in Ouagadougou. A retrospective study covered a period of two years, from 1 January 2013 to 31 December 2014 in a private clinic in Ouagadougou. Patients included in the study were hospitalized for fever and painful syndrome with a positive test to the dengue non-structural antigen 1 (NS1 Ag). Ninety-eight cases of dengue on 343 suspected cases were registered. The average age of patients was 35.9 years. The sex-ratio (M/F) was 1.18. According to the professional activity, there was a predominance of civil servants (35.7%). The pain syndrome was found in 93.9% of patients. Leukopenia (73.5%), neutropenia (56.1%) and severe thrombocytopenia (57.1%) were the predominant hematological disturbances. Of the patients, 18.4% had hemorrhagic dengue and 11.2%, a dengue shock syndrome. Four patients died. The use of non-steroidal antiinflammatory drugs was associated with the severity of the infection (p=0.04). Dengue fever occurs in our context and constitutes a risk of mortality. The diagnosis of dengue should be performed systematically in front of a painful and febrile syndrome. The vector control is the best way of prevention against dengue pending the development of a vaccine.


Subject(s)
Dengue/diagnosis , Dengue/epidemiology , Hospitalization/statistics & numerical data , Adolescent , Adult , Aged , Burkina Faso/epidemiology , Child , Child, Preschool , Dengue/pathology , Disease Progression , Female , Hospitals, Private , Humans , Male , Middle Aged , Retrospective Studies , Young Adult
2.
Ann Dermatol Venereol ; 143(10): 607-610, 2016 Oct.
Article in French | MEDLINE | ID: mdl-27476377

ABSTRACT

BACKGROUND: Ecthyma gangrenosum is an acute ulcer necrotic skin infection frequently caused by Pseudomonas aeruginosa. It is characterised by necrotic ulcerations circumscribed by an inflammatory halo. Lesions are normally found in the anal, genital and axillary regions. Ecthyma gangrenosum is most commonly seen in immunodepressed patients (cytotoxic chemotherapy, HIV infection, neutropenia or functional neutrophil deficiency, agammaglobulinemia). It is a rarely described complication in chicken pox. PATIENTS AND METHODS: Herein we report the case of a girl aged 2 ½ years presenting in our dermatology department with ecthyma gangrenosum on the right upper eyelid secondary to varicella. The disease course was marked by fibrous scarring of the inner canthus with ptosis of the right upper eyelid. The retractile scarring caused disability. DISCUSSION: There have been previous reports of the contribution of non-steroidal anti- inflammatory drugs (NSAIDs) to the appearance of necrotic cutaneous super infections during the course of chickenpox. The occurrence of such complications on an eyelid may be harmful not only for the function of the eye but it can also cause extensive aesthetic impairment. Subsequent aesthetic and functional impairment may be improved by corrective surgery.


Subject(s)
Chickenpox/complications , Ecthyma/complications , Eyelid Diseases/microbiology , Pseudomonas Infections/complications , Blepharoptosis/etiology , Child, Preschool , Female , Humans , Pseudomonas aeruginosa/isolation & purification
3.
Bull Soc Pathol Exot ; 108(1): 36-40, 2015 Feb.
Article in French | MEDLINE | ID: mdl-25012097

ABSTRACT

The Fondation Mérieux, in partnership with the Ministries of Health of Burkina Faso, Mali and Senegal, implemented for four years a project to reinforce the laboratory sector in the three participating countries: the RESAOLAB project (West African Network of Biomedical Analysis Laboratories).The objective of RESAOLAB project, in partnership with the WHO Office for West Africa and the West African Health Organization, was to strengthen the systems of biomedical laboratories to improve diagnostic services, access, monitoring and management of infectious diseases. Following the successful results achieved under the RESAOLAB project and due to the demand of the neighbour countries ministries, the RESAOLAB project is now extended to four other countries of the West African region: Benin, Guinea-Conakry, Niger and Togo. The RESAOLAB project has become the RESAOLAB programme, its purpose is to strengthen the quality of the medical biology services thanks to a regional and transversal approach.


Subject(s)
Clinical Laboratory Techniques/standards , Laboratories/organization & administration , Quality Improvement/organization & administration , Africa, Western , Benin , Cooperative Behavior , Guinea , Humans , Medical Laboratory Personnel/education , Medical Laboratory Personnel/organization & administration , Medical Laboratory Personnel/statistics & numerical data , Niger , Quality Assurance, Health Care/organization & administration , Quality Improvement/standards , Togo , Workforce
5.
Pak J Biol Sci ; 14(10): 578-83, 2011 May 15.
Article in English | MEDLINE | ID: mdl-22097093

ABSTRACT

Borassus aetihiopum MART (Arecaceae) is a plant used in traditional herbal medicine for the treatment of various diseases (bronchitis, laryngitis, antiseptic). In particular, their male inflorcscences were reported to exhibit cicatrizing, antiseptic and fungicidal properties. In the present study, the biological activity of E2F2, an apolar extract from Borassus aethiopum male inflorescence was investigated on colon cancer HT29 cells. Phytochemical screening was carried according to methodology for chemical analysis for vegetable drugs. Cells proliferation was determined by the MTT assay and cells cycle distribution was analysed by using laser flow cytometer (Beckman coulter). The cytoskeleton organisation was examined under a laser scanning confocal microscope (Zess). Preliminary phytochemical analysis of E2F2 extract revealed the presence of sterols, triterpenes and saponosids. E2F2 extract (1 microg and 100 microg mL(-1)) significantly inhibited cell proliferation by blocking cell population in G0/G1 phase. Flow Cytometric analysis of E2F2-treated HT29 cells showed that hypoploïd cell population (sub G1 phase) increased with processing time exposures. Immunofluorescence confocal analysis revealed a disrupt actin microfilaments network in E2F2 treated-cells with a significant reduction in actin stress fibres and appearance of a random, non-oriented distribution of focal adhesion sites. These data indicate that E2F2 extract has anti-proliferative and pro-apoptotic activities. Further studies are required to unravel the mechanisms of action of E2F2 extract.


Subject(s)
Apoptosis/drug effects , Arecaceae/chemistry , HT29 Cells/drug effects , Plant Extracts/chemistry , Plant Extracts/pharmacology , Cell Proliferation/drug effects , Colonic Neoplasms/drug therapy , Drug Screening Assays, Antitumor , Humans , Medicine, African Traditional , Methanol/chemistry , Methylene Chloride/chemistry , Phytotherapy , Plant Extracts/therapeutic use
6.
C R Biol ; 332(4): 371-7, 2009 Apr.
Article in French | MEDLINE | ID: mdl-19304267

ABSTRACT

Pharmacological studies were conducted with the aqueous extract of the bark of the stem of Ximenia americana Linne (Olacaceae) on experimental animals, evaluating the analgesic activities. In the analgesic test, the aqueous extract elicited an inhibitory intensity on the acetic acid-induced writhing response and on the late phase of the formalin test, but possessed only a weak effect on the tail-flick response and on the early phase of the formalin test.


Subject(s)
Analgesics, Non-Narcotic/pharmacology , Olacaceae/chemistry , Analgesics, Opioid/pharmacology , Animals , Formaldehyde , Mice , Morphine/pharmacology , Pain Measurement/drug effects , Phenylbutazone/pharmacology , Plant Bark/chemistry , Plant Extracts/pharmacology , Plant Extracts/toxicity , Plant Stems/chemistry , Rats , Rats, Wistar , Reaction Time/drug effects
7.
Bull Soc Pathol Exot ; 99(4): 241-4, 2006 Oct.
Article in French | MEDLINE | ID: mdl-17111970

ABSTRACT

Sickle cell anemia being involved in oxidizing stress, our objective was to study the influence of the fetal haemoglobin rate (FHb) on the lipoperoxidation markers in homozygote sickle cell patient in tropical African surroundings. The study population was composed of 73 subjects among whom 57 homozygote sickle cell subjects and 16 healthy control cases. These subjects were distributed in 4 groups according to FHb rate: group 1 (FHb rate under 10%), group 2 (FHb rate ranging from 10 and 20%), group 3 (FHb rate above 20%), group 4 (control cases with no sickle cell disease). On the biological level, the markers of plasma lipoperoxidation represented by substances reacting with thiobarbituric acid (TBARS) significantly increased in sickle cell patients comparatively to control cases (p = 10(-6)). A strong positive correlation (r = +0,70, p<0,01) was found between HbS and the TBARS rate. Comparison of biological parameters of homozygote sickle cell patients according to HbF rate shows that TBARS rate is all the more low as the HbF rate is high (p = 0,02). Moreover the number of irreversible and reversible sickle cells is higher in the group 1 which has the highest rate of TBARS. This observation is confirmed by a coefficient of positive correlation between TBARS and reversible sickle cells (r = +0,40, p < 0,01). This study strengthens the role played by HbF on the modulation of physiopathology of homozygote sickle cell anemia by the control, among others, of free radicals.


Subject(s)
Anemia, Sickle Cell/blood , Anemia, Sickle Cell/metabolism , Fetal Hemoglobin/analysis , Oxidative Stress , Adolescent , Adult , Anemia, Sickle Cell/genetics , Child , Child, Preschool , Cote d'Ivoire , Cross-Sectional Studies , Female , Homozygote , Humans , Male
8.
Mali Med ; 21(1): 8-11, 2006.
Article in French | MEDLINE | ID: mdl-17390522

ABSTRACT

Burkina Faso belongs to the sicklemic's belt of LEHMAN and is the epicenter of haemoglobin C. This is the reason of this study on the haematological and biochemical parameters of homozygotes SS and double heterozygotes SC in stationary stage. These parameters will be use for comparison during crisis and to evaluate the therapy efficiency. So 20 homozygotes and 20 double heterozygotes were studied. The blood film showed anaemia with an haemoglobin rate average of 7.8 g/dl for SS against 9.8 g/dl for SC (p < 0.001). An serum's iron elevated in 26.3% of the SS with an average of 23 micromoles /l against 36.8% with an average of 21.7 micromoles /l in the SC (p < 0.001). These results show the importance of SS anaemia's and biochemical's disorders in comparison to the SC.


Subject(s)
Anemia, Sickle Cell/metabolism , Anemia, Sickle Cell/blood , Bilirubin/blood , Child , Female , Hemoglobins/analysis , Humans , Male , Mali
10.
Ann Biol Clin (Paris) ; 63(5): 507-12, 2005.
Article in French | MEDLINE | ID: mdl-16230286

ABSTRACT

Many authors reported metabolic perturbations in connection with HIV infection. The aim of this studies was to determinate plasma lipids profile in non treated HIV infected adults in Ouagadougou (Burkina Faso). The results obtain with 187 HIV infected patients showed a significative (p < 10(-6)) high level of LDL, triglycerid, atherogenic indice; HDL was decreased. The atherogenic risk is increased with lymphocytes CD4 depletion. Plasma lipids levels must be consider in the choice of antiretroviral treatment.


Subject(s)
HIV Infections/blood , Lipids/blood , Adolescent , Adult , Burkina Faso , CD4-Positive T-Lymphocytes/immunology , Female , HIV Infections/immunology , Humans , Lipoproteins, HDL/blood , Lipoproteins, LDL/blood , Lymphocyte Depletion , Male , Middle Aged , Triglycerides/blood
11.
Ann Biol Clin (Paris) ; 62(2): 229-34, 2004.
Article in French | MEDLINE | ID: mdl-15047477

ABSTRACT

In order to establish reference values of biochemical profile of the adult (n = 559) in tropical sahelian area (Burkina Faso), assumed to be healthy, age between 15 and 50, 15 clinical blood constituents appearing among the most commonly explored were determined. Most constituents levels are influenced by sex et and age. The reference values stemming from the adult native of Burkina Faso were compared with those of the european adult and difference ares observed.


Subject(s)
Blood Chemical Analysis , Adolescent , Adult , Burkina Faso , Female , Humans , Male , Middle Aged , Reference Values
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