ABSTRACT
Thirty-four patients with herpes simplex dendritic keratitis were randomized into three treatment categories: Group A had débridement alone; group B, trifluridine (trifluorothymidine) alone; and group C, débridement and trifluridine. Patients treated with débridement alone had a statistically higher failure rate than did the other two groups. No statistically significant difference was observed between trifluridine treatment alone and débridement combined with trifluridine treatment, with regard to healing time. Our results suggest that débridement alone is suboptimal therapy for herpes simplex dendritic keratitis and that débridement combined with trifluridine appears to offer no advantage over trifluridine alone.
Subject(s)
Debridement , Keratitis, Dendritic/drug therapy , Thymidine/analogs & derivatives , Trifluridine/therapeutic use , Adolescent , Adult , Aged , Combined Modality Therapy , Female , Humans , Keratitis, Dendritic/surgery , Male , Middle AgedABSTRACT
Thirteen eyes with sterile marginal corneal ulcers were treated with cryotherapy and conjunctival recession or resection. Ulcer progression was ultimately controlled in all cases (mean follow-up of 21 months). One eye with Mooren's ulcer required reoperation to achieve a quiescent state, and two other eyes needed conservative therapy after surgery in order to heal. The eyes required careful observation for ulcer recurrence or problems associated with the original systemic diseases, such as Sjögren's syndrome. In the majority of cases, visual acuity was not affected by the procedure. Light microscopy of the conjunctiva adjacent to the ulcer showed lymphocytes and plasma cells.
