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Survival of Mesenchymal Stem Cells in Different Methods of Nebulization.

Aver'yanov, A V; Konoplyannikov, A G; Antonov, N S; Osipova, G L; Vasil'eva, O S; Sakharova, M G; Tatarskii, A R; Kobylyansky, V I.

Bull Exp Biol Med ; 164(4): 576-578, 2018 Mar.

Article in English | MEDLINE | ID: mdl-29504107

ABSTRACT

We compared survival of bone marrow mesenchymal stem cells after compressor, ultrasound, and mesh nebulization of the cell suspension over 10 min. Viability of stromal cells was best preserved after compressor nebulization (72%). Cell survival after ultrasonic nebulization was significantly lower (20%). After mesh nebulization, no live cells were found. Thus, compressor nebulization is the most preferable method of the production of cell aerosol for their delivery to the lower respiratory tract.

Subject(s)

Bone Marrow Cells/cytology , Cell- and Tissue-Based Therapy/instrumentation , Mesenchymal Stem Cells/cytology , Administration, Inhalation , Bone Marrow Cells/physiology , Cell Survival , Cell- and Tissue-Based Therapy/methods , Filtration , Humans , Infusion Pumps , Mesenchymal Stem Cells/physiology , Nebulizers and Vaporizers , Pressure , Ultrasonic Waves

ABSTRACT

Subject(s)

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