ABSTRACT
The present study is focused on evaluating the antimutagenic properties of Schiff bases and Mn(III) complexes with L-Threonine, L-Serine and L-Tyrosine, which have antimicrobial activity. These six compounds were investigated for antimutagenic properties against Aflatoxin Bi (AFBi) by the micronucleus (MN) assay in a human lymphocyte cell culture in vitro. The protective role of these compounds against AFBi-induced MN is probably related to its doses. A mechanism has been proposed to reduce the effect of AFBi.
Subject(s)
Aflatoxin B1 , Anti-Bacterial Agents , Antidotes , Azo Compounds , Manganese , Serine , Thiosemicarbazones , Threonine , Tyrosine , Aflatoxin B1/antagonists & inhibitors , Aflatoxin B1/toxicity , Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/pharmacology , Antidotes/chemistry , Antidotes/pharmacology , Azo Compounds/chemistry , Azo Compounds/pharmacology , Bacteria/growth & development , Female , Humans , Male , Manganese/chemistry , Manganese/pharmacology , Serine/chemistry , Serine/pharmacology , Thiosemicarbazones/chemistry , Thiosemicarbazones/pharmacology , Threonine/chemistry , Threonine/pharmacology , Tyrosine/chemistry , Tyrosine/pharmacologyABSTRACT
This study was conducted to evaluate the antimutagenic and antimicrobial activities of Schiff bases attached L-glutamine and L-asparagine. Antibacterial activities of the compounds against S. aureus, Sh. dys. typ 7, L. monocytogenes 4b, E. coli, S. typhi H, S. epidermis, Br. abortus, M. luteus, B. cereus, P. putida, and antifungal activity against Candida albicans were studied. These compounds were investigated for antimutagenic properties against Aflatoxin Bi (AFBi) using micronuclei (MN) assay in human lymphocyte cell culture in vitro. The protective role of these compounds against AFBi-induced MN is probably related to its doses.
Subject(s)
Asparagine/chemistry , Asparagine/pharmacology , Glutamine/chemistry , Glutamine/pharmacology , Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/pharmacology , Antifungal Agents/chemistry , Antifungal Agents/pharmacology , Antimutagenic Agents/chemistry , Antimutagenic Agents/pharmacology , Bacteria/drug effects , Candida albicans/drug effects , Female , Humans , Lymphocytes/drug effects , Lymphocytes/metabolism , Male , Manganese/chemistry , Micronucleus Tests , Schiff Bases/chemistryABSTRACT
The in vitro antibacterial and antifungal activities of five different amino acid Schiff bases derived from the reaction of 2-hydroxy-1-naphthaldehyde with glycine, L-alanine L-phenylalanine, L-histidine, L-tryptophane and the manganese(III) complexes of these bases were investigated. Structures of the Schiff bases were proven by 1H-NMR. In vitro activities against some Gram-positive (Staphylococcus aureus and Bacillus polymyxa) and Gram-negative (Escherichia coli) bacteria and the fungus Candida albicans were determined. The antimicrobial activities tended to decrease with the increasing size of the amino acid residues.
