ABSTRACT
Hepatitis B Virus (HBV) e antigen (HBeAg), HBV DNA and precore mutations affecting HBeAg expression during active replication were studied in 72 Tunisian hepatitis B surface antigen (HBsAg) positive individuals: 30 asymptomatic carriers of the virus, 37 with chronic hepatitis and 5 with acute hepatitis. HBV DNA was detected in 44 patients, but only 20% of them expressed HBeAg. Precore mutant strains, with mutations at position 1896 or at positions 1896 and 1899, were detected by PCR-hybridization in 86 and 36% of patients, respectively. Wild-type strains were detected in 54% of patients. Precore mutants were found in chronically and in acutely infected individuals, in patients with severe and asymptomatic infections, in HBeAg positive as well as HBeAg negative individuals. These results show the high frequency of HBV precore mutants in Tunisia.
Subject(s)
Hepatitis B virus/genetics , Hepatitis B/epidemiology , Mutation , Promoter Regions, Genetic/genetics , Viral Core Proteins/genetics , DNA Primers , DNA, Viral/blood , Gene Expression Regulation, Viral , Hepatitis B/blood , Hepatitis B/virology , Hepatitis B e Antigens/blood , Humans , Polymerase Chain Reaction , Tunisia/epidemiologySubject(s)
Chemical and Drug Induced Liver Injury/etiology , Methyldopa/adverse effects , Adverse Drug Reaction Reporting Systems , Chemical and Drug Induced Liver Injury/blood , Chemical and Drug Induced Liver Injury/complications , Chemical and Drug Induced Liver Injury/economics , Chemical and Drug Induced Liver Injury/pathology , Cholestasis/etiology , Drug Costs , Drug Utilization , Female , Humans , Middle AgedSubject(s)
Gastritis/pathology , Gastritis/physiopathology , Helicobacter Infections/pathology , Helicobacter Infections/physiopathology , Helicobacter pylori , Adolescent , Adult , Aged , Aged, 80 and over , Biopsy , Child , Female , Gastritis/diagnosis , Gastritis/epidemiology , Gastroscopy , Helicobacter Infections/diagnosis , Helicobacter Infections/epidemiology , Humans , Incidence , Male , Middle Aged , Prospective StudiesSubject(s)
Gastrointestinal Hemorrhage/epidemiology , Liver Cirrhosis/complications , Adolescent , Adult , Aged , Child , Clinical Protocols , Decision Trees , Female , Gastrointestinal Hemorrhage/etiology , Gastrointestinal Hemorrhage/therapy , Humans , Male , Middle Aged , Recurrence , Tunisia/epidemiologySubject(s)
Lymphangiectasis, Intestinal , Protein-Losing Enteropathies , Adolescent , Adult , Child , Humans , Middle AgedSubject(s)
Immunoproliferative Small Intestinal Disease/complications , Lymphoma/complications , Pancreatic Neoplasms/complications , Adolescent , Humans , Immunoproliferative Small Intestinal Disease/drug therapy , Immunoproliferative Small Intestinal Disease/immunology , Lymphoma/immunology , Male , Pancreatic Neoplasms/immunology , Remission InductionSubject(s)
Echinococcosis, Hepatic/complications , Jaundice/etiology , Adolescent , Adult , Aged , Child , Female , Humans , Male , Middle AgedSubject(s)
Carrier State/pathology , Hepatitis B/pathology , Liver/pathology , Adolescent , Adult , HumansABSTRACT
A case of angiodysplasia of the right colon is reported. Clinical, radiological, endoscopic and pathological aspects are described. Beside the arteriography, the authors insist on the special usefulness of the coloscopy which helps the diagnosis and gives therapeutic possibilities as well by electrocoagulation of the lesion. Vascular opacification of the specimen is very useful to help the pathologist.
