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1.
A ratiometric fluorescent probe for imaging hydroxyl radicals in living cells.
Soh, Nobuaki; Makihara, Koji; Sakoda, Emino; Imato, Toshihiko.
Chem Commun (Camb) ; (5): 496-7, 2004 Mar 07.
Article in English | MEDLINE | ID: mdl-14973575

ABSTRACT

A novel fluorescent probe, the detection mechanism of which is based on the 'on-off' switching of a FRET triggered by the *OH-induced cleavage of a DNA strand, has been developed for the ratiometric imaging of *OH.


Subject(s)
Cells/chemistry , Cells/metabolism , Hydroxyl Radical/chemistry , Cell Physiological Phenomena , Diagnostic Imaging , Fluorescent Dyes , Spectrometry, Fluorescence , Ultraviolet Rays
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