1.
Chem Pharm Bull (Tokyo)
; 49(11): 1500-2, 2001 Nov.
Article
in English
| MEDLINE
| ID: mdl-11724250
ABSTRACT
Improved synthesis of the trans-3,5-disubstituted pyrrolidin-3-ylthio side-chain of the novel carbapenem 1 was achieved via stereoselective reduction of the 1-aryl-1-butanone derivative 5 and successive intramolecular cyclization of the resulting chiral alcohol 6. The 1-aryl-1-butanone derivative 5 was obtained by a coupling reaction of protected 4-hydroxy-2-pyrrolidone with aryl-Grignard reagent.
Subject(s)
Carbapenems/chemical synthesis , Carbapenems/chemistry , Stereoisomerism
2.
Nihon Shishubyo Gakkai Kaishi
; 28(2): 639-45, 1986 Jun.
Article
in Japanese
| MEDLINE
| ID: mdl-3466974