Analysis of Plasma Skimming within a Hydrodynamic Bearing Gap for Designing Spiral Groove Bearings in Rotary Blood Pumps.

The blood damage problem inside the narrow hydrodynamic bearing is potentially considered to be solved by applying plasma skimming. However, the consideration of improving plasma skimming has not been included in the design of hydrodynamic bearings. The absence of experimental investigation on revealing the relationship between blood flow and plasma skimming in the bearing gap impedes the design of groove shape for plasma skimming. Thus, the present study was undertaken to evaluate how the blood flow direction and the groove shape affect plasma skimming in the bearing gap. To this end, blood tests using porcine blood were repeated three times with a hematocrit of 0.8%. The bearing gap during the tests was adjusted to 25 µm and the rotational speed was adjusted from 50 rpm to 2500 rpm. The blood flow and plasma skimming effect was evaluated based on image analysis utilizing a high-speed microscope. Results of three tests indicated that the flow direction of RBCs was dominated by the rotating surface in the bearing gap when the rotational speed increased over 1200 rpm. The best plasma skimming effect was observed when the angle between the flow direction of RBCs and the tangent line of the groove was within -10 degrees to 10 degrees. The future study will be conducted with including the consideration of plasma skimming in the bearing shape design. The findings in this study aid the future design and development of hydrodynamic bearing for use in rotary blood pumps.

Evaluating Plasma Skimming with Whole Blood in Small Gap Region Imitating Clearance of Blood Pumps.

Plasma skimming is the phenomenon whereby the discharge hematocrit is lower than feed hematocrit naturally occurring in the microvessels with Poiseuille flow. It has been studied in Poiseuille flow extensively. Besides, plasma skimming has also been observed and investigated in blood pumps due to its potential to prevent hemolysis by skimming blood cells out of the small gap. However, whether plasma skimming occurs in blood pumps with whole blood has not been verified. Additionally, the independent influence of rotational speed and gap size has not been clarified. Therefore, in order to lay the foundation of applying plasma skimming to the development of blood pumps and also investigate the influence of rotational speed and gap size on plasma skimming respectively, we designed a simplified geometric device which not only imitates the flow inside clearances of blood pumps, but also provides different rotational speed and gap size conditions. We first conducted the verification tests of plasma skimming using whole blood with an initial hematocrit of 44% and the gap size was varied from 10 µm to 240 µm with 10 µm interval. The plasma skimming was verified occurring when the gap was less than 70 µm at a rotational speed of 800 rpm. Since plasma skimming was confirmed, we employed 30% hematocrit blood and performed the following tests to evaluate the influence of rotational speed of 600 rpm, 700 rpm, and 800 rpm respectively. As a result, the hematocrit of sampled blood declined as the rotational speed increased from 600 rpm to 800 rpm. And there was the lowest hematocrit of 16% when the gap was adjusted to 50 µm gap size at 800 rpm. This study further promotes the possibility of applying plasma skimming to the blood pumps with higher hemocapability.

Application of a magnetic fluid seal to rotary blood pumps.

A magnetic fluid seal enables mechanical contact-free rotation of a shaft without frictional heat and material wear and hence has excellent durability. However, the durability of a magnetic fluid seal decreases in liquid. The life of a seal applied to a rotary blood pump is not known. We have developed a magnetic fluid seal that has a shield mechanism minimizing the influence of the rotary pump on the magnetic fluid. The developed magnetic fluid seal worked for over 286 days in a continuous flow condition, for 24 days (on-going) in a pulsatile flow condition and for 24 h (electively terminated) in blood flow. The magnetic fluid seal is promising as a shaft seal for rotary blood pumps.