Subject(s)
Amputation, Surgical , Bone Regeneration , Bone and Bones/metabolism , Osteogenesis , Animals , Bone and Bones/blood supply , Bone and Bones/diagnostic imaging , Diphosphates , Dogs , Pentetic Acid , Radionuclide Imaging , Technetium , Technetium Tc 99m Pentetate , Technetium Tc 99m PyrophosphateABSTRACT
Blood circulation was studied in 68 patients with closed oblique and spiral fractures of the leg bones in the middle and lower thirds in the injured segment using 99mTc-DTPA and 133Xe. The normal rate of the blood flow in the cortical layer of the tibial diaphysis was 0.008 +/- 0.0006 ml/g bone/min and in the bone marrow 0.030 +/- 0.002 ml/min. After fracture the rate of the blood flow increased reaching its maximum values (3.6 times increase) in the 5th week, then it decreased and returned to normal by the 70th day. In the bone marrow the maximum value of the blood flow was noted on the 5th day; on the 14th day it decreased significantly. In the cortical layer the maximum values of the blood flow acceleration (by 7.5 times) were established on the 14th day and persisted up to the 23rd day. The return to normal was observed on the 90th day.
