[Effectiveness of gentamicin sulfate in suppurative-inflammatory processes of varying localization]. / Effektivnost' gentamitsina sul'fata pri gnoino-vospalitel'nykh protsessakh razlichnoi lokalizatsii.

Antibiotic sensitivity of 486 strains of grampositive and gramnegative organisms isolated from patients with purulent infections was studied in vitro. Gentamicin was shown to be highly active as compared to kanamycin and other antibiotics against the main causative agents of purulent inflammatory infections including multiresistant E. coli, Proteus, Ps. aeruginosa, Staphylococcus. High efficiency of gentamicin in therapy of peritonitis, septic conditions, purulent postoperative wounds, infections of the urinary tract, pneumonia, etc. (197 patients) was shown. Positive results were obtained in 87.4 per cent of the cases. Side effects, such as albuminuria, hyperthermic reaction, rash, pruritus were registered in 3 per cent of the patients.

[Use of aminoglycosides and other antibacterial preparations in gastroenterology]. / Primenenie aminoglikozidov i drugikh antibakterial'nykh preparatov v gastroénterologii.

Kanamycin and monomycin were used in the treatment of 945 severe surgical patients. Examination of antibiograms showed that the microflora of the patients was moderately and highly sensitive. The antibotic blood levels defined the tactics of the drug administration rate and route. The antibiotic treatment was accompanied by complex therapy for increasing the host protective forces. The antibiotic treatment was well tolerated by the patients. No impairements of the kidneys or the VIII pair of the cranial nerve were observed. Allergic reactions in the form of urticaria were registered in several patients.