ABSTRACT
Totally 38 aryl E 2-propen-1-ones including nine substituted styryl 4-iodophenyl ketones have been synthesised using solvent-free SiO2-H3PO4 catalyzed Aldol condensation between respective methyl ketones and substituted benzaldehydes under microwave irradiation. The yields of the ketones are more than 80%. The synthesised chalcones were characterized by their analytical, physical and spectroscopic data. The spectral frequencies of synthesised substituted styryl 4-iodophenyl ketones have been correlated with Hammett substituent constants, F and R parameters using single and multi-linear regression analysis. The antimicrobial activities of 4-iodophenyl chalcones have been studied using Bauer-Kirby method.
Subject(s)
Anti-Infective Agents/chemistry , Anti-Infective Agents/pharmacology , Chalcones/chemistry , Chalcones/pharmacology , Alkenes/chemical synthesis , Alkenes/chemistry , Alkenes/pharmacology , Anti-Infective Agents/chemical synthesis , Bacteria/drug effects , Bacterial Infections/drug therapy , Catalysis , Chalcones/chemical synthesis , Fungi/drug effects , Humans , Mycoses/drug therapyABSTRACT
A series of aryl imines have been synthesized by Fly-ash: H2SO4 catalyzed microwave assisted process under solvent-free conditions. The yields of the imines have been found to be more than 87%. The purity of all imines has been checked using their physical constants and spectral data as published earlier in literature. The UV λmaxCN(nm), infrared νCN(cm(-1)), NMR δ(ppm) of CH and CN spectral data have been correlated with Hammett substituent constants and F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effect of substituents on the above spectral data has been studied. The antimicrobial activities of All synthesised imines have been studied using Bauer-Kirby method.
Subject(s)
Anti-Infective Agents/chemistry , Anti-Infective Agents/pharmacology , Hydrocarbons, Aromatic/chemistry , Hydrocarbons, Aromatic/pharmacology , Imines/chemistry , Imines/pharmacology , Anti-Infective Agents/chemical synthesis , Bacteria/drug effects , Bacterial Infections/drug therapy , Fungi/drug effects , Humans , Hydrocarbons, Aromatic/chemical synthesis , Imines/chemical synthesis , Magnetic Resonance Spectroscopy , Mycoses/drug therapy , Spectrophotometry, Infrared , Spectrophotometry, UltravioletABSTRACT
A series of 2-naphthyl pyrazolines were synthesized by the cyclization of 2-naphthyl chalcones and phenylhydrazine hydrochloride in the presence of sodium acetate. The yields of pyrazoline derivatives are more than 80%. The synthesized pyrazolines were characterized by their physical constants, IR, (1)H, (13)C and MS spectra. From the IR and NMR spectra the C=N (cm(-1)) stretches, the pyrazoline ring proton chemical shifts (ppm) of δ(Ha), H(b) and H(c) and also the carbon chemical shifts (ppm) of δC=N are correlated with Hammett substituent constants, F and R, and Swain-Lupton's parameters using single and multi-regression analyses. From the results of linear regression analysis, the effect of substituents on the group frequencies has been predicted. The antimicrobial activities of all synthesized pyrazolines have been studied.
