ABSTRACT
The initial stages of nonischemic chronic heart failure in rats (model of oleothorax) were accompanied by the development of dyslipidemia. This state was characterized by an increase in total cholesterol concentration (due to the fraction of low-density lipoproteins) and atherogenicity index. The concentrations of plasma total cholesterol and low-density lipoproteins were shown to decrease in animals with severe course of nonischemic chronic heart failure. These changes were accompanied by a decrease in the atherogenicity index. Intragastric administration of cholesterol had little effect on the lipid composition of blood plasma in rats, irrespective of the severity of heart failure.
Subject(s)
Heart Failure/metabolism , Lipid Metabolism , Animals , Cholesterol/blood , Cholesterol/classification , Chronic Disease , RatsABSTRACT
The present study confirms involvement of the sympathicoadrenal system in adaptation of heart to overload. Besides, at formation of chronic heart failure (CHF) there have been revealed a rise of the histamine and serotonin levels in blood plasma and myocardium as well as glucocorticoid hyperactivation.
Subject(s)
Adaptation, Physiological , Heart Failure/metabolism , Heart Failure/physiopathology , Heart/physiopathology , Myocardium/metabolism , 11-Hydroxycorticosteroids/blood , 11-Hydroxycorticosteroids/metabolism , Animals , Catecholamines/blood , Catecholamines/metabolism , Chronic Disease , Disease Models, Animal , Heart/innervation , Heart Failure/blood , Histamine/blood , Histamine/metabolism , Male , Rats , Rats, Wistar , Serotonin/blood , Serotonin/metabolismABSTRACT
Simulation of chronic heart failure in rats led to an increase in heart rate variability and decrease in heart rate. All beta-blockers also promoted the heart rate variability augmentation in ill animals. The most potent effects on heart rate variability were produced by pindolol, atenolol, and propranolol. Bisoprolol and metoprolol affected heart rate and heart rate variability in less extent, and nebivolol normalized a part of heart rate variability parameters.
Subject(s)
Adrenergic beta-Antagonists/pharmacology , Heart Failure , Heart Rate/drug effects , Animals , Atenolol/pharmacology , Benzopyrans/pharmacology , Bisoprolol/pharmacology , Ethanolamines/pharmacology , Heart Failure/drug therapy , Male , Metoprolol/pharmacology , Nebivolol , Pindolol/pharmacology , Propranolol/pharmacology , RatsABSTRACT
In narcotized rats, beta-adrenoceptor blockers changed all parameters of heart rate variability indicating up-regulation of parasympathetic activity and down-regulation of the sympathetic one. In immobilized awake rats, the temporal and geometrical parameters varied similarly, while spectral analysis indicated possible activation of other neurohumoral mechanisms against the background of beta-blocker treatment.
Subject(s)
Adrenergic beta-Antagonists/pharmacology , Heart Rate/drug effects , Animals , Atenolol/pharmacology , Electrocardiography , Male , Parasympathetic Nervous System/drug effects , Parasympathetic Nervous System/physiology , Propranolol/pharmacology , Rats , Sympathetic Nervous System/drug effects , Sympathetic Nervous System/physiology , WakefulnessABSTRACT
Lipophilic inhibitors of angiotensin-converting enzyme increased 6-month survival and/or lifetime of rats with experimental chronic heart failure. These drugs had no effect on the mortality rate of animals with acute decompensation of the disease. beta-Adrenoceptor blockers without intrinsic sympathomimetic activity not only prolonged 6-month survival and lifetime, but also decreased the mortality rate of rats with decompensation of chronic heart failure.
Subject(s)
Adrenergic beta-Antagonists/therapeutic use , Angiotensin-Converting Enzyme Inhibitors/therapeutic use , Cardiac Output, Low/drug therapy , Cardiac Output, Low/mortality , Adrenergic beta-Antagonists/pharmacokinetics , Adrenergic beta-Antagonists/pharmacology , Angiotensin-Converting Enzyme Inhibitors/pharmacokinetics , Angiotensin-Converting Enzyme Inhibitors/pharmacology , Animals , Disease Models, Animal , Rats , Rats, Inbred StrainsABSTRACT
The method of application wound sorption with sorbent Vaulen was used in treatment of erysipelatous inflammation in 49 patients. The first signs of healing appeared 1.5-2 times quicker, the rate of lessening the area of the wound surface was 21-35% greater. The period of staying in the hospital was 20-23% shorter.
