ABSTRACT
An otherwise healthy 34-year-old man presented to our clinic with a small nonhealing, tender papule that had appeared on his face 9 months previously. His family history and past medical history were unremarkable. There was no history of trauma. Cutaneous examination revealed a small erythematous papule 0.5 cm in diameter on the left preauricular region (Figure 1). There was no regional lymphadenopathy, and he was in a generally good condition.
Subject(s)
Facial Neoplasms/diagnosis , Leiomyosarcoma/diagnosis , Skin Neoplasms/diagnosis , Adult , Cheek , Facial Neoplasms/pathology , Humans , Leiomyosarcoma/pathology , Male , Skin Neoplasms/pathologyABSTRACT
A 50-year-old woman presented to our dermatology clinic with pruritic lesions on her hands that had appeared 24 hours earlier. The clinical manifestations had started 24 hours after taking 100 mg of doxycycline for acute bronchitis. She had no history of allergic disease or allergic reactions to drugs. The dermatologic examination revealed multiple erythematous, purplish annular patches with overlying bullae with hemorrhagic content on both palms (Figure 1). The patient had no fever, and the rest of the physical examination did not reveal any abnormalities. Results of laboratory tests were within normal limits. A skin biopsy was performed, showing hydrophic degenerations of the basal membrane, a superficial perivascular infiltrate consisting of lymphocytes and eosinophils, and red blood cells in the dermis (Figure 2). A pharmacovigilance investigation was conducted, and doxycycline was confirmed as the agent responsible for the bullous fixed drug eruption (FDE) in our patient.
