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1.
Article in English | MEDLINE | ID: mdl-37947555

ABSTRACT

BACKGROUND: Studies indicate a higher prevalence of mental health problems among immigrants, but findings on immigrant children and adolescents are mixed. We sought to understand the magnitude of differences in mental health indicators between immigrant and non-immigrant children and adolescents in Canada and the influence of age, sex, household income, and household education. METHODS: We completed a secondary analysis of data from the Canadian Health Measures Survey, using a pooled estimate method to combine data from four survey cycles. A weighted logistic regression was used to estimate the unadjusted and adjusted odds ratios with 95% confidence intervals. RESULTS: We found an association between the mental health of immigrant versus non-immigrant children and adolescents (6-17 years) as it relates to emotional problems and hyperactivity. Immigrant children and adolescents had better outcomes with respect to emotional problems and hyperactivity/inattention compared to non-immigrant children and adolescents. Lower household socioeconomic status was associated with poorer mental health in children and adolescents. CONCLUSION: No significant differences in overall mental health status were evident between immigrant and non-immigrant children and adolescents in Canada but differences exist in emotional problems and hyperactivity. Sex has an influence on immigrant child mental health that varies depending on the specific mental health indicator.


Subject(s)
Emigrants and Immigrants , Mental Health , Humans , Child , Adolescent , Canada/epidemiology , Health Surveys , Surveys and Questionnaires
2.
Reprod Sci ; 29(10): 2894-2907, 2022 10.
Article in English | MEDLINE | ID: mdl-35349119

ABSTRACT

Preterm birth accounts for the majority of perinatal mortality worldwide, and there remains no FDA-approved drug to prevent it. Recently, we discovered that the common drug excipient, N,N-dimethylacetamide (DMA), delays inflammation-induced preterm birth in mice by inhibiting NF-κB. Since we reported this finding, it has come to light that a group of widely used, structurally related aprotic solvents, including DMA, N-methyl-2-pyrrolidone (NMP) and dimethylformamide (DMF), have anti-inflammatory efficacy. We show here that DMF suppresses LPS-induced TNFα secretion from RAW 264.7 cells and IL-6 and IL-8 secretion from HTR-8 cells at concentrations that do not significantly affect cell viability. Like DMA, DMF protects IκBα from degradation and prevents the p65 subunit of NF-κB from translocating to the nucleus. In vivo, DMF decreases LPS-induced inflammatory cell infiltration and expression of TNFα and IL-6 in the placental labyrinth, all to near baseline levels. Finally, DMF decreases the rate of preterm birth in LPS-induced pregnant mice (P<.0001) and the rate at which pups are spontaneously aborted (P<.0001). In summary, DMF, a widely used solvent structurally related to DMA and NMP, delays LPS-induced preterm birth in a murine model without overt toxic effects. Re-purposing the DMA/DMF/NMP family of small molecules as anti-inflammatory drugs is a promising new approach to delaying or reducing the incidence of inflammation-induced preterm birth and potentially attenuating other inflammatory disorders as well.


Subject(s)
Dimethylformamide , Premature Birth , Acetamides , Animals , Anti-Inflammatory Agents/pharmacology , Dimethylformamide/adverse effects , Disease Models, Animal , Excipients/adverse effects , Female , Humans , Infant, Newborn , Inflammation/chemically induced , Inflammation/drug therapy , Inflammation/prevention & control , Interleukin-6 , Interleukin-8 , Lipopolysaccharides/pharmacology , Mice , NF-KappaB Inhibitor alpha , NF-kappa B/metabolism , Placenta/metabolism , Pregnancy , Premature Birth/chemically induced , Premature Birth/prevention & control , Solvents/adverse effects , Tumor Necrosis Factor-alpha
3.
Am J Pathol ; 185(3): 862-9, 2015 Mar.
Article in English | MEDLINE | ID: mdl-25579843

ABSTRACT

Premature delivery occurs in 12% of all births, and accounts for nearly half of long-term neurological morbidity, and 60% to 80% of perinatal mortality. Despite advances in obstetrics and neonatology, the rate of premature delivery has increased approximately 12% since 1990. The single most common cause of spontaneous preterm birth is infection. Several lines of evidence have demonstrated the role of endothelin-1 as both a constrictor of uterine myometrial smooth muscle and a proinflammatory mediator. Endothelin-1 activates the phospholipase C pathway, leading to activation of protein kinase C and, in turn, sphingosine kinase (SphK). The inhibition of SphK has been recently shown to control the proinflammatory response associated with sepsis. We show herein, for the first time, that SphK inhibition prevents inflammation-associated preterm birth in a murine model. Rescue of pups from premature abortion with an SphK inhibitor occurs by suppression of the proinflammatory cytokines tumor necrosis factor α, Il-1ß, and Il-6 and attenuation of polymorphonuclear inflammatory cells into the placental labyrinth. Moreover, we postulate that inhibition of SphK leads to suppression of endothelin-converting enzyme-1 expression, indicating the presence of an endothelin-converting enzyme 1/endothelin 1-SphK positive feedback loop. This work introduces a novel approach for the control of infection-triggered preterm labor, a condition for which there is no effective treatment.


Subject(s)
Cytokines/metabolism , Enzyme Inhibitors/therapeutic use , Phosphotransferases (Alcohol Group Acceptor)/antagonists & inhibitors , Placenta/metabolism , Premature Birth/prevention & control , Animals , Disease Models, Animal , Enzyme Inhibitors/pharmacology , Female , Inflammation/metabolism , Lipopolysaccharides , Mice , Phosphotransferases (Alcohol Group Acceptor)/metabolism , Placenta/drug effects , Pregnancy , Premature Birth/chemically induced , Premature Birth/metabolism
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