ABSTRACT
High-grade gliomas (World Health Organization grade III-IV) are highly lethal primary brain tumors. Imaging modalities, including MRI and FDG PET, provide a limited ability to differentiate treatment effects (such as radiation necrosis) from recurrent or residual tumor. As the first step in validating the applicability of prostate-specific membrane antigen (PSMA)-targeted imaging in high-grade gliomas, we evaluated the ability of the PSMA-targeted small molecule [F]DCFPyL (2-(3-(1carboxy-5-(6-[F]fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid) to image high-grade gliomas in a series of 3 prospectively recruited patients. We found [F]DCFPyL binds PSMA in the neovasculature of glioblastoma multiforme and tumor cells of anaplastic astrocytoma.
Subject(s)
Antigens, Surface/metabolism , Brain Neoplasms/diagnostic imaging , Brain Neoplasms/pathology , Glioma/diagnostic imaging , Glioma/pathology , Glutamate Carboxypeptidase II/metabolism , Lysine/analogs & derivatives , Urea/analogs & derivatives , Brain Neoplasms/metabolism , Glioma/metabolism , Humans , Magnetic Resonance Imaging , Male , Neoplasm Grading , Positron-Emission TomographyABSTRACT
The incidence of congenital heart disease requiring specialized care is 2.5 to 3 per 1000 live births with a prevalence of congenital heart disease of 81.4 per 10,000 live births. Total cavopulmonary or atriopulmonary connection, used for palliation of certain types of congenital heart disease, diverts flow from the vena cava or atrium directly into the pulmonary arteries. Altered anatomy in patients who have undergone this intervention may result in contrast and/or radiotracer localizing preferentially to a single lung leading to interpretation errors and redundant studies. Performing bilateral upper-extremity injections for this patient population may reduce such technical errors and redundant studies.
Subject(s)
Computed Tomography Angiography , Fontan Procedure , Heart Defects, Congenital/diagnostic imaging , Heart Ventricles/abnormalities , Vena Cava, Superior/diagnostic imaging , Adult , Female , Heart Defects, Congenital/surgery , Heart Ventricles/diagnostic imaging , Heart Ventricles/surgery , Humans , Vena Cava, Superior/abnormalities , Vena Cava, Superior/surgeryABSTRACT
Subcutaneous F-FDG uptake is a common finding on PET scans, with causes including both benign and malignant conditions. Often, the pattern of uptake or the clinical indication for the PET scan will suggest the etiology. However, unusual or unexpected patterns may require careful clinical history. We report the case of a 45-year-old woman who underwent a PET/CT study for paraneoplastic syndrome evaluation and was found to have intense, extensive, bilaterally symmetric, nodular subcutaneous FDG uptake in the lower back and buttocks that was related to long-term repeated subcutaneous opioid injections.
