Paciente de 32 años con fiebre, esplenomegalia y pancitopenia / No disponible

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El volumen plaquetario en el diagnóstico diferencial de las trombopenias centrales y periféricas / Platelet volume in the differential diagnosis of central and peripheral thrombocytopenia

Objetivos. Analizar la utilidad del volumen plaquetario medio (VPM) en el diagnóstico diferencial de las trombopenias centrales y periféricas. Casuística. Métodos: Se estudiaron 26 trombopenias centrales y 54 trombopenias periféricas, 20 de estas se estudiaron también después de la curación. El recuento de plaquetas y el volumen plaquetario se realizaron en un autoanalizador multicanal acoplado al contador automático de partículas. Se estudiaron 20 controles normales. Resultados: En el grupo control el VPM es significativamente mayor que en las trombopenias centrales. El VPM es significativamente mayor en las trombopenias periféricas que en los controles y que en las trombopenias centrales. Conclusiones. El VPM es una determinación rápida, útil y fácil para el diagnóstico diferencial entre las trombopenias centrales (microtrombocitarias) de las perioféricas (macrotombocitarias)

Objectives: To analyses the usefulness of mean platelet volume (MPV) in the differential diagnosis of central and peripheral thrombocytopenia. Population and methods: Twenty-six patients with central thrombocytopenia, fifty-four patients with peripheral thrombocytopenia and twenty healthy controls were included. Twenty of these patients were studied after the resolution of the process too. Platelet count an MPV were performed in all subjects using a multichannel autoanalyzer connected to an automatic particle counter. Results: MPV was significantly higher in the control group when compared with the central thrombocytopenia group. MPV was significantly higher in the peripheral thrombocytopenia group than in both the control and the central thrombocytopenia groups. Conclusions: MPV is an easy fast and useful determination for the differential diagnosis between central (microthrombocytic) and peripheral (macrothombocytic) thrombocytopenia

Plasma fibronectin concentrations in patients with HIV infection and visceral leishmaniasis.

Concentrations of circulating fibronectin were studied in plasma of 22 patients with acquired immunodeficiency syndrome and 24 healthy blood donors. There were significant differences between the plasma fibronectin values of the patient population with AIDS (mean 2 SD = 206 +/- 86 mg/l) and of the control group (mean +/- 2 SD = 297 +/- 92 mg/l). AIDS patients with visceral leishmaniasis showed a significant diminution of plasma fibronectin concentration (mean +/- 2 SD = 132 +/- 31 mg/l). A significant increase in plasma fibronectin concentrations was noted after 14 days of treatment with antimony (mean 2 SD = 239 +/- 67 mg/l). These results suggest that the measurement of fibronectin concentrations in patients with AIDS especially with concurrent infection, contributes to diagnosis. A significant decrease in plasma fibronectin concentrations was observed in patients with AIDS and visceral leishmaniasis.

[Imported malaria: 6 cases, 2 of them with an erythrocyte glucose-6-phosphate dehydrogenase deficiency]. / Paludismo importado: seis observaciones, dos con déficit en glucosa-6-fosfato deshidrogenasa eritrocitaria.

We present six cases of imported malaria in Spanish and foreign patients who had visited or lived in areas of malaria endemic. Two patients presented deficit of erythrocytic glucose-6-phosphate dehydrogenase. The main aspects of these two pathologies are analyzed, stressing their similar geographic distribution and the mechanisms by which such deficit protects against the malaria infection. In addition, we describe the problems that may arise with the use of anti-malaria in carriers of this enzymatic deficit; in our patients, the use of chloroquine did not raise any problem.