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Rev Med Chir Soc Med Nat Iasi ; 120(1): 173-7, 2016.
Article in English | MEDLINE | ID: mdl-27125092

ABSTRACT

AIM: To determine during the first trimester of pregnancy some serum and ultrasound markers that could improve perinatal morbidity and mortality in women with intrauterine growth restriction (IUGR). MATERIAL AND METHODS: Prospective study of pregnant women gestational age 11 weeks and 0 days--13 weeks and 6 days, consisting in the determination of pregnancy associated plasma protein (PAPP-A), mean platelet volume (MPV), and ultrasound appearance of placenta. DISCUSSION AND CONCLUSIONS: This study suggests that screening by detailed history and PAPP-A and MPV determination during the first trimester of pregnancy in women at risk for IUGR makes possible the prophylactic treatment and monitoring of pregnancy according to a given protocol and thus neonatal morbidity and mortality to be reduced.


Subject(s)
Fetal Growth Retardation/blood , Fetal Growth Retardation/diagnosis , Mean Platelet Volume , Pregnancy-Associated Plasma Protein-A/metabolism , Ultrasonography, Prenatal , Biomarkers/blood , Female , Fetal Growth Retardation/metabolism , Fetal Growth Retardation/prevention & control , Humans , Predictive Value of Tests , Pregnancy , Pregnancy Outcome , Pregnancy Trimester, First , Prenatal Diagnosis , Prospective Studies , Risk Factors , Sensitivity and Specificity
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