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1.
Immune reconstitution inflammatory syndrome associated with PML in AIDS: a treatable disorder.
Martinez, J V; Mazziotti, J V; Efron, E D; Bonardo, P; Jordan, R; Sevlever, G; Martinez, M; Verbanaz, S C; Salazar, Z Salazar; Pardal, M Fernandez; Reisin, R.
Neurology ; 67(9): 1692-4, 2006 Nov 14.
Article in English | MEDLINE | ID: mdl-17101910

ABSTRACT

An HIV-1-infected patient with progressive multifocal leukoencephalopathy presented clinical deterioration and contrast-enhancing lesions on brain nuclear MR after the initiation of highly active antiretroviral therapy (HAART). Brain biopsy identified an inflammatory reaction compatible with immune reconstitution inflammatory syndrome. Treatment with corticosteroids and transient suppression of HAART led to marked neurologic improvement.


Subject(s)
Acquired Immunodeficiency Syndrome/complications , Antiretroviral Therapy, Highly Active/adverse effects , Brain/drug effects , Encephalitis/chemically induced , Encephalitis/immunology , Leukoencephalopathy, Progressive Multifocal/drug therapy , Adult , Anti-Inflammatory Agents/therapeutic use , Aphasia/chemically induced , Aphasia/immunology , Aphasia/physiopathology , Brain/immunology , Brain/pathology , Chemotaxis, Leukocyte/drug effects , Chemotaxis, Leukocyte/immunology , Dexamethasone/therapeutic use , Encephalitis/physiopathology , Hemiplegia/chemically induced , Hemiplegia/immunology , Hemiplegia/physiopathology , Humans , Inclusion Bodies/immunology , Inclusion Bodies/pathology , Inclusion Bodies/virology , JC Virus/immunology , JC Virus/isolation & purification , Leukoencephalopathy, Progressive Multifocal/physiopathology , Leukoencephalopathy, Progressive Multifocal/virology , Macrophages/drug effects , Macrophages/immunology , Magnetic Resonance Imaging , Male , Oligodendroglia/immunology , Oligodendroglia/pathology , Oligodendroglia/virology , T-Lymphocytes/drug effects , T-Lymphocytes/immunology , Treatment Outcome , Withholding Treatment
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