ABSTRACT
In a girl with the Chediak-Higashi syndrome, a remarkable polymorphism of chromosome number one was identified by G and C banding. The association of the polymorphisms of constitutive heterochromatin with abnormal phenotypes is discussed. It is suggested that further cytogenetic studies might be performed in humans and animals with this rare autosomal recessive disorder in order to confirm the present findings.
Subject(s)
Chediak-Higashi Syndrome/genetics , Chromosome Aberrations , Chromosomes, Human, 1-3 , Polymorphism, Genetic , Adolescent , Chromosome Banding , Female , HumansSubject(s)
Immunity, Cellular , Liver Cirrhosis, Alcoholic/immunology , Adult , Chronic Disease , Humans , Male , Middle AgedABSTRACT
Some aspects of cell-mediated immunity were explored in a population of 51 patients with active pulmonary tuberculosis in comparison with 30 apparently healthy volunteers randomly taken from the Mexican general population. Evaluation included DNCB sensitization, PPD skin test, determination of LIF, E and EAC-rosette formation and the ability of lymphocytes to survive in culture through periods of up to 48 hours. The results for the in vivo assays showed significant differences between the compared populations since the frequency of a positive PPD skin test was higher in the patients (p = 0.0000004) but only 60.8% of them responded to DNBC (p = 0.006). It was expected that there would be some impairment in the production of LIF and in the number of E-rosettes, however, this did not occur. Survival of lymphocytes in culture demonstrated an altered population of cells, probably weak even before blood samples were taken, in the tuberculosis group (p = 0.05). Furthermore, cell mortality was very notable in patients with cavitated and infiltrative lesions, after 48 hours culture (p = 0.015 and 0.02 respectively) suggesting the presence of a population of cells unable to function optimally.
Subject(s)
Tuberculosis, Pulmonary/immunology , Adolescent , Adult , Aged , Child , Female , Humans , Immunity, Cellular , Immunization , Male , Middle Aged , Rosette Formation , Tuberculin TestSubject(s)
Onchocerciasis/parasitology , Adolescent , Adult , Child , Child, Preschool , Female , Humans , Male , Onchocerca/isolation & purificationSubject(s)
Onchocerciasis/epidemiology , Central America , Female , Humans , Male , Mexico , South AmericaABSTRACT
Thirty patients suffering from scabies who had previonsly received other kinds of treatment were administered "Metrifonate" at daily doses of 10 mg./kg. b.w. during two consecutive days repeated every week and associated with atropine sulfate. The number of weeks lapse until the treatment finished was as follows. (see article.) Four patients developed intolerance, but it was transitory (nausea and vomiting). Cures (skin lesions and prutitus) were obtaind in 29 our of 30 cases.
