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1.
Rev. esp. med. legal ; 47(1): 41-44, ene.-mar. 2021. ilus
Article in Spanish | IBECS | ID: ibc-202352

ABSTRACT

El nuevo coronavirus SARS-CoV-2 ha causado miles de muertes alrededor del mundo. La mayoría de los fallecimientos ocurren en instalaciones sanitarias; sin embargo, un número indeterminado de enfermos fallecen de manera súbita, inesperada o repentina en diversos lugares y representan casos de interés médico legal. Compartimos los hallazgos del estudio microscópico de muestras de pulmón de un caso de muerte inesperada de un paciente positivo por COVID-19 que permanecía en aislamiento domiciliario. Nuestras observaciones corroboran la endotelialitis, trombosis y angiogénesis como distintivos de la patología pulmonar de esta nueva enfermedad, hallazgos con implicaciones clínicas y terapéuticas


The new SARS-CoV-2 coronavirus has caused thousands of deaths around the world. Most deaths occur in healthcare facilities. However, an undetermined number of patients die suddenly, unexpectedly in a variety of places and are cases of medical legal interest. We share the findings of the microscopic study of lung samples from a COVID-19 positive patient who died unexpectedly at home in quarantine. Our observations confirm endothelialitis, thrombosis and angiogenesis as microscopic hallmarks of the lung pathology of this new disease. These findings have clinical and therapeutic implications


Subject(s)
Humans , Male , Middle Aged , Coronavirus Infections/pathology , Lung/pathology , Pneumonia, Viral/mortality , Morphological and Microscopic Findings , Cause of Death , Coronavirus Infections/mortality , Betacoronavirus , Pneumonia, Viral/pathology , Thrombosis/mortality , Thrombosis/pathology , Immunohistochemistry
2.
Rev. esp. med. legal ; 46: 0-0, 2020. ilus
Article in Spanish | IBECS | ID: ibc-194392

ABSTRACT

El nuevo coronavirus SARS-CoV-2 ha causado miles de muertes alrededor del mundo. La mayoría de los fallecimientos ocurren en instalaciones sanitarias; sin embargo, un número indeterminado de enfermos fallecen de manera súbita, inesperada o repentina en diversos lugares y representan casos de interés médico legal. Compartimos los hallazgos del estudio microscópico de muestras de pulmón de un caso de muerte inesperada de un paciente positivo por COVID-19 que permanecía en aislamiento domiciliario. Nuestras observaciones corroboran la endotelialitis, trombosis y angiogénesis como distintivos de la patología pulmonar de esta nueva enfermedad, hallazgos con implicaciones clínicas y terapéuticas


The new SARS-CoV-2 coronavirus has caused thousands of deaths around the world. Most deaths occur in healthcare facilities. However, an undetermined number of patients die suddenly, unexpectedly in a variety of places and are cases of medical legal interest. We share the findings of the microscopic study of lung samples from a COVID-19 positive patient who died unexpectedly at home in quarantine. Our observations confirm endothelialitis, thrombosis and angiogenesis as microscopic hallmarks of the lung pathology of this new disease. These findings have clinical and therapeutic implications


Subject(s)
Humans , Male , Middle Aged , Coronavirus Infections/complications , Severe Acute Respiratory Syndrome/pathology , Severe acute respiratory syndrome-related coronavirus/pathogenicity , Endothelium, Vascular/pathology , Thrombosis/pathology , Neovascularization, Pathologic/pathology , Forensic Pathology/methods , Fatal Outcome , Lung/pathology , Autopsy/statistics & numerical data , Polymerase Chain Reaction/methods , Histocytochemistry/methods
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