ABSTRACT
TITLE: Prevalencia de alteraciones en el neurodesarrollo en niños de población rural de Oaxaca evaluados mediante la prueba de evaluación de desarrollo infantil.
Subject(s)
Neurodevelopmental Disorders , Rural Population , Child , Humans , Prevalence , Child Development , Environment , Neurodevelopmental Disorders/diagnosis , Neurodevelopmental Disorders/epidemiologySubject(s)
Humans , Male , Female , Child , Neurodevelopmental Disorders , Rural Population , Child Development , Psychology, Developmental , Neurology , Nervous System Diseases , Mexico , Pediatrics , Psychology, ChildABSTRACT
PURPOSE: To describe the clinical characteristics of ocular involvement in patients with pemphigus at an ophthalmological referral center. METHODS: A retrospective review was conducted on patients with the immunopathological diagnosis of pemphigus examined between 1 January 2000 and 1 April 2010. Uncorrected distance visual acuity (UDVA), best corrected distance visual acuity (BCVA), ocular symptoms, and ocular surface inflammatory and scarring changes were assessed. RESULTS: A total of 15 patients were identified, with a mean age of 68.27 ± 14.35 years, and 80% (n=12) were female. Extraocular involvement was reported in one patient. All of the eyes showed cicatricial changes in the conjunctiva. In all, 6 eyes (20%) were classified as stage I; 12 eyes (40%) as stage II; 10 eyes (33%) as stage III; and 2 eyes (7%) as stage IV. A statistically significant association was found between BCVA and the severity of ocular involvement. The mean BCVA logMAR was 1.66 (20/914), with a range from logMAR 0 (20/20) to logMAR 4 (NLP). Other ocular diseases were found in 8 (53.3%), systemic diseases in 10 (66.7%), and the use of pemphigus-inducing drugs in 10 patients (66.7%). CONCLUSIONS: The present report represents the largest series of ocular involvement in pemphigus confirmed by immunopathology. The clinical manifestations varied from conjunctival hyperemia to corneal scarring and perforation. There was a strong association between scarring changes and low BCVA. Ocular and systemic diseases as well as the use of pemphigus-inducing drugs may predispose to ocular cicatricial changes observed in this series.
Subject(s)
Cicatrix/pathology , Conjunctival Diseases/pathology , Pemphigus/pathology , Aged , Aged, 80 and over , Conjunctival Diseases/drug therapy , Conjunctival Diseases/etiology , Female , Follow-Up Studies , Humans , Immunosuppressive Agents/therapeutic use , Male , Middle Aged , Pemphigus/complications , Pemphigus/drug therapy , Retrospective Studies , Severity of Illness Index , Visual AcuityABSTRACT
A 54 years old female patient with a mitral valve prolapse and a rheumatic arthritis with steroids was admitted with dysnea and hypotension, that started 30 min after taking a pill containing enapril and hydroclorothiazide. Hemodynamic monitoring with a Swan-Ganz catheter showed a pulmonary capillary pressure of 5 mm Hg, a systemic vascular resistance of 887 (dyn sec)/cm5 and a cardiac output of 10 1/min. Tha patient had a history of adverse reactions to thiazides and responded to volume replacement, dopamine and steroids
