ABSTRACT
The results of a study of fibrosis in acute and chronic diseases of the liver are presented. Different forms of liver fibrosis (intralobular, portal, and septal) were shown to occur with various frequency in liver diseases and to be of dissimilar significance in diagnosis, clinical manifestation and evolution of the disease, and evaluation of its prognosis.
Subject(s)
Connective Tissue/pathology , Liver/pathology , Biliary Tract Diseases/pathology , Diagnosis, Differential , Hepatitis/pathology , Histocytochemistry , Humans , Liver Cirrhosis/pathology , PrognosisABSTRACT
The connective tissue in liver biopsies from 880 patients with acute and chronic liver diseases was studied by means of the modern morphological methods--histochemistry, histoenzymology and electronmicroscopy. It was found that various forms of liver fibrosis (intralobular, portal and septal ones) accompany liver pathology with various frequency. They are of different value in the clinical manifestation and development, in diagnostics and prognostic estimates in each case.
Subject(s)
Connective Tissue/pathology , Liver Diseases/pathology , Adult , Aged , Biopsy , Female , Humans , Liver/pathology , Liver/ultrastructure , Liver Cirrhosis/pathology , Male , Microscopy, Electron , Middle Aged , PrognosisSubject(s)
Liver/pathology , Syphilis/pathology , Adult , Female , Humans , Liver/physiopathology , Liver Function Tests , Male , Middle Aged , Syphilis/physiopathology , Time FactorsABSTRACT
The conducted clinico-experimental study (an investigation of the functional and morphological state of the liver in impaired bile outflow) indicated different compensatory reactions. It is the authors' opinion that bile congestion in the liver is accompanied with proliferation of bile ducts; a damaging effect of bile components, in the first place bilious acids, is manifested in pericholangitis, periductal fibrosis and later in the development of biliary cirrhosis; alterations of the parenchyma occur secondarily also as a result of the toxic effect of bilous components and show a focal character.
Subject(s)
Cholestasis/pathology , Liver/pathology , Adult , Aged , Bile/analysis , Bile Acids and Salts/analysis , Bile Acids and Salts/blood , Bilirubin/analysis , Bilirubin/blood , Cholelithiasis/complications , Cholestasis/etiology , Cholestasis/physiopathology , Female , Humans , Hyperbilirubinemia/etiology , Liver/physiopathology , Male , Middle Aged , Pancreatic Neoplasms/complicationsABSTRACT
Results of histological, histochemical and electron-microscopy studies of puncture-biopsy specimens of the liver of 25 patients with alcoholic hepatitis are discussed. It is shown that acute alcoholic hepatitis develops, develops, as a rule against the background of steatosis and hepatocirrhosis as a result of the previous chronic consumption of alcohol. Lesions of the liver in this disease are of cholestatic character, which was due to the impairment of the metabolism of lipids, cholesterol and biliary acids under the effect of ethanol. The microscopic picture of alcoholic hepatitis is characterized by the presence of Mallory hyalin, intracellular congestion of the bile and predominance of neutrophilic leukocytes in the cell infiltrate. The characteristics make it possible to differentiate alcoholic hepatitis from viral one.
Subject(s)
Alcoholism/pathology , Chemical and Drug Induced Liver Injury/pathology , Cholestasis/pathology , Liver/pathology , Adult , Aged , Bile/metabolism , Chemical and Drug Induced Liver Injury/metabolism , Cholestasis/etiology , Cholestasis/metabolism , Female , Hepatitis B/metabolism , Hepatitis B/pathology , Humans , Hyalin , Lipid Metabolism , Liver/metabolism , Liver Glycogen/metabolism , Male , Middle Aged , RNA/metabolismABSTRACT
Reparative processe were studied on bioptic specimens taken from 190 patients with virus hepatitis. Figures of nitosis, amounts of binuclear and polyloid hepatocytes served as criteria of regneration. Phenomena of regeneration were shown to continue during the entire period of the disease. They were most pronounced in the areas adjacent to the zone of lesion of the parenchyma. A leading reparative process was intracellulr regneration.
