ABSTRACT
Procarbazine hydrochloride is an oral alkylating agent with activity against lymphoma. It is most commonly used in the treatment of Hodgkin's disease. The use of procarbazine-containing chemotherapeutic regimens in non-Hodgkin's lymphoma fell out of favor with the advent of CHOP. We report two patients with relapsed and/or refractory follicular lymphoma that achieved a complete and durable remission with a prolonged course of daily procarbazine.
Subject(s)
Lymphoma, Non-Hodgkin/drug therapy , Procarbazine/therapeutic use , Adult , Alkylating Agents/therapeutic use , Antineoplastic Agents/pharmacology , Enzyme Inhibitors/pharmacology , Female , Humans , Male , Middle Aged , Monoamine Oxidase Inhibitors/pharmacology , Remission Induction , Stem Cell Transplantation/methodsSubject(s)
Biopsy, Needle/adverse effects , Hematoma/etiology , Adult , Bone Marrow Examination/adverse effects , Female , Hematocrit , Hematoma/diagnostic imaging , Humans , Inguinal Canal , Male , Middle Aged , Pancytopenia/complications , Platelet Transfusion , Purpura, Thrombocytopenic, Idiopathic/complications , Thigh , Tomography, X-Ray ComputedABSTRACT
Because of its wide prevalence and its grave consequences on the health of older persons, malnutrition requires immediate attention. Physicians in general have been described as being nutritionally blind in their slowness to recognize undernutrition. A high degree of suspicion, a thorough history and physical examination, and pertinent laboratory data can identify patients at risk. When a more comprehensive assessment is needed; screening tools, dietary history, and special biochemical parameter can be used.
