ABSTRACT
Burning mouth syndrome (BMS) is characterised by the presence of a burning sensation in the oral mucosa in the absence of any clinically apparent mucosal sign. It occurs more commonly in older women and often affects the tongue tip and lateral borders, lips, and hard and soft palates. Besides the burning sensation, patients with BMS may complain of unremitting oral mucosal pain, dysgeusia, and xerostomia. The exact pathophysiology of primary BMS remains unknown. A major challenge for the clinician is the treatment of BMS: identifying possible causative factors is the first step, but BMS is often idiopathic. Drug therapy, in addition to behavioural therapy and psychotherapy, may help to eliminate the symptoms. Considering the growing incidence of BMS in older people, further research is required to determine the true efficacy of current management strategies for patients with this disorder.
Subject(s)
Burning Mouth Syndrome/therapy , Benzylamines/administration & dosage , Burning Mouth Syndrome/diagnosis , Burning Mouth Syndrome/epidemiology , Burning Mouth Syndrome/physiopathology , Capsaicin/administration & dosage , Capsaicin/therapeutic use , Clonazepam/administration & dosage , Humans , Lidocaine/administration & dosage , PrevalenceABSTRACT
Fibro-osseous lesions (FOL) represent a heterogeneous group of lesions that exhibit a variety of clinic-pathological features. Recently, based on the new World Health Organization classification system, these lesions were reclassified as follows: (1) fibrous dysplasia (FD), (2) osseous dysplasia, and (3) ossifying fibroma. Nevertheless, the nosologic placement of FOL may be problematic because of substantial overlap in the histopathological findings. In this study, we analyzed 10 cases of FD by both optical and confocal laser scanning microscopy, a research technique based on the laser light microscopic analysis of stained biological samples that allows improved tissue imaging and bidimensional pictures with high resolution at the cellular level to provide a better understanding of the diagnosis of this disease.
Subject(s)
Craniofacial Abnormalities/pathology , Fibrous Dysplasia of Bone/pathology , Microscopy, Confocal/methods , Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Young AdultABSTRACT
Confocal microscope was used to analyze human enamel from 10 deciduous and 10 permanent teeth. Optically sectioned images were obtained. A more intense autofluorescence was found in primary teeth. This finding might be due to the greater presence of organic substances in deciduous enamel. The mean prism diameter measurement in permanent teeth enamel was 3.150 µm and 2.602 µm in deciduous teeth. The mean prism diameter in deciduous teeth was statistically least. The results indicate that a confocal microscope may be of help in analyzing and defining the microscopic features of human enamel.
Subject(s)
Dental Enamel/ultrastructure , Microscopy, Electron, Scanning , Tooth, Deciduous/ultrastructure , Tooth/ultrastructure , Adolescent , Adult , Female , Humans , Male , Optical Imaging/methods , Young AdultABSTRACT
Oral Lichen Planus (OLP) is a common disease of unknown aetiology affecting oral mucosae by T-cell mediated chronic inflammation. OLP diagnosis is made by evaluating both clinical and histological criteria. Pharmacological treatment is useful in symptomatic cases. Life-long clinical follow-up is essential, due to low-risk of malignant transformation. In vivo Reflectance Confocal Microscopy (RCM) offers a real-time virtual biopsy of the being tissues and does not require surgical excision nor histopathological processing. RCM was used to capture OLP lesions in order to clinically differentiate them from other clinical entities.
Subject(s)
Autoimmunity/immunology , Lichen Planus, Oral/diagnosis , Lichen Planus, Oral/epidemiology , Lichen Planus, Oral/etiology , Lichen Planus, Oral/immunology , Retinoids/therapeutic use , T-Lymphocytes/pathology , Biological Factors/therapeutic use , Cyclosporine/therapeutic use , Diagnosis, Differential , Humans , Lichen Planus, Oral/drug therapy , Microscopy, Confocal/methods , Tacrolimus/therapeutic useABSTRACT
Candida albicans is a dimorphic yeast strongly gram positive able to live as normal commensal organism in theoral cavity of healthy people. It is the yeast more frequently isolated in the oral cavity. Under local and systemicfactors related to the host conditions, it becomes virulent and responsible of oral diseases known as oral candidiasis.It has been shown that the presence of denture is a predisposing factor to the onset of pathologies related toC. albicans. Clinical studies have shown that C. albicans is not only able to adhere to the mucous surfaces, but alsoto stick to the acrylic resins of the dental prostheses. Both the plaque accumulated on the denture and the poororal hygiene contribute to the virulence of Candida, offering the clinical picture of Candida-associated denturestomatitis. The therapeutic strategies currently adopted in the clinical practice to overcome these fungal infectionsprovide for the use of topical and/or systemic antifungal and topical antiseptics and disinfectants, the irradiationwith microwaves and the accurate mechanical removal of the bacterial plaque from the denture surfaces and fromthe underlying mucosa. A correct oral hygiene is important for the control of the bacterial biofilm present on thedenture and on the oral mucosa and it is the fundamental base for the prophylaxis and the therapy of the Candidaassociateddenture stomatitis (AU)
Subject(s)
Humans , Candida albicans/pathogenicity , Candidiasis, Oral/microbiology , Stomatitis/microbiology , Biofilms/growth & development , Prosthesis-Related Infections/microbiologyABSTRACT
Candida albicans is a dimorphic yeast strongly gram positive able to live as normal commensal organism in the oral cavity of healthy people. It is the yeast more frequently isolated in the oral cavity. Under local and systemic factors related to the host conditions, it becomes virulent and responsible of oral diseases known as oral candidiasis. It has been shown that the presence of denture is a predisposing factor to the onset of pathologies related to C. albicans. Clinical studies have shown that C. albicans is not only able to adhere to the mucous surfaces, but also to stick to the acrylic resins of the dental prostheses. Both the plaque accumulated on the denture and the poor oral hygiene contribute to the virulence of Candida, offering the clinical picture of Candida-associated denture stomatitis. The therapeutic strategies currently adopted in the clinical practice to overcome these fungal infections provide for the use of topical and/or systemic antifungal and topical antiseptics and disinfectants, the irradiation with microwaves and the accurate mechanical removal of the bacterial plaque from the denture surfaces and from the underlying mucosa. A correct oral hygiene is important for the control of the bacterial biofilm present on the denture and on the oral mucosa and it is the fundamental base for the prophylaxis and the therapy of the Candida-associated denture stomatitis.
Subject(s)
Candidiasis , Stomatitis, Denture/microbiology , Candidiasis/etiology , Candidiasis/therapy , Humans , Stomatitis, Denture/etiology , Stomatitis, Denture/therapyABSTRACT
En el presente trabajo se evalúa la calidad de las aguas y las posibles fuentes de contaminación de la cuenca superior del Río Sauce Grande que, a través del dique Paso de las Piedras, abastece de agua potable a la ciudad de Bahía Blanca(300.000 hab.). Teniendo en cuenta la construcción de tal infraestructura se analiza el posible impacto ambiental a fin de lograr determinar un índice de calidad ambiental regional
