1.
Nucleosides Nucleotides Nucleic Acids
; 24(5-7): 1075-9, 2005.
Article
in English
| MEDLINE
| ID: mdl-16248095
ABSTRACT
A new method has been investigated for the functionalization of gold nanoparticles with DNA. Silica-coated nanoparticles functionalized with a maleimide have been prepared. These particles are designed to react with modified DNA containing a diene functionality at one end of the molecule. The result would be the formation of a more stable attachment of the DNA to the particle through a Diels-Alder reaction. This covalent attachment would not be susceptible to ligand exchanges, which are known to occur in the conventional DNA functionalization of gold nanoparticles.