[The assessment of the interferon status of term newborns born to mothers with chronic nonspecific lung diseases]. / Otsenka sostoianiia interferonovogo statusa u donoshennykh novorozhdennykh, rodivshikhsia u materei s khronicheskimi nespetsificheskimi zabolevaniiami legkikh.

The study involved 34 full-term newborn babies born by mothers with chronic nonspecific diseases of the lungs and 10 newborns born by mothers with the physiological course of pregnancy and parturition, the examinations being carried out in the early neonatal period. A lower capacity for production of endogenous and gamma-interferons at delivery and on day 6 of life as well as a higher incidence of intrauterine and postnatal infections were observed in the newborns of the first group. This indicated the necessity to consider such babies as a group at risk of developing neonatal complications. The data of the study may be used for early diagnosis and prognosis of perinatal infections.

[The functional characteristics of the prostacyclin-thromboxane system in newborn infants with a history of acute and chronic intrauterine hypoxia]. / Osobennosti sostoianiia protsatsiklin-tromboksanovoi sistemy u novorozhdennykh detei, perenesshikh ostruiu i khronicheskuiu vnutriutrobnuiu gipoksiiu.

Specific features of the prostacyclin-thromboxan system were revealed in 122 newborns with perinatal hypoxia of various severity in the course of the early neonatal period. Differences in blood prostacyclin and thromboxan levels and their ratio were revealed in newborns who suffered different forms of hypoxia and adaptation disturbances of varying severity. The most pronounced and stubborn changes were characteristic of infants with a history of grave chronic intrauterine hypoxia.

[Characteristics of central and peripheral hemodynamics in infants with hemolytic disease of newborn]. / Osobennosti tsentral'noi i perifericheskoi gemodinamiki u novorozhdennykh s gemoliticheskoi bolezn'iu.

Overall 82 full-term neonates (52 children with hemolytic disease and 30 healthy neonates) were examined. The general circulation was investigated over time (on days 1, 3.5-7 of life). Use was made of echocardiography and monitor studies of arterial pressure and heart rate; lability of arterial pressure and general peripheral vascular resistance were computed. As a result of the studies and correlations, it has been revealed that neonates with hemolytic disease manifest appreciable disorders of the cardiovascular system, correlating with the disease gravity. Earlier times of the closure of fetal communications were established as were the hyperkinetic type of +cardiac hemodynamics, arterial hypotension accompanied by arterial pressure instability and a decrease of the general peripheral vascular resistance which should be taken into consideration in choosing therapeutic measures.

[Status of the cardiovascular system of the fetus and newborn infant in different degree of severity of maternal hypertensive syndrome]. / Sostoianie serdechno-sosudistoi sistemy ploda i novorozhdennogo pri razlichnoi stepeni tiazhesti gipertenzivnogo sindroma u materi.

Examinations of 260 pregnant women with hypertensive syndromes and their 60 full-term newborns, carried out with the use of echography of the umbilical artery, umbilical vein, aorta, and internal carotid artery of the fetus have demonstrated a high informative value of these methods for the assessment of the type of fetal condition and prediction of the newborn's adaptive mechanisms of the cardiovascular system. Significant changes of the cardiovascular system were revealed in small-for-date fetuses and in chronic fetal hypoxia, as well as functional changes in the newborns of the mothers with the hypertensive syndrome, with born signs of intrauterine suffering. These changes should be borne in mind when predicting the development of infants born of mothers with the hypertensive syndrome.

[Hormonal regulation of glycemia and metabolic adaptation of newborn babies with intrauterine hypotrophy]. / Gormonal'naia reguliatsiia glikemii i metabolicheskaia adaptatsiia novorozhdennyk/h s vnutriutrobnoi gipotrofiei.

The content of hormones that regulate carbohydrate metabolism was studied during the early neonatal period in 80 full-term neonates with intrauterine hypotrophy. Early application to the breast (2 to 6 hours after the birth) was shown to promote the normalization of the hormonal content. The levels of blood serum C-peptide in the newborn depend on the degree of the rise of the mother's body weight during pregnancy and the presence of toxicosis. The levels of cortisol, somatotropic hormone, immunoreactive insulin and C-peptide were determined by the degree of morphological immaturity of the tissues whereas the content of STH and cortisol by the intensity of hypotrophy as well. The moment of the birth and the early neonatal period of children with intrauterine hypotrophy is characterized by a decrease of the activity of lactate dehydrogenase, alpha-hydroxybutyrate dehydrogenase, creatine kinase and aspartate aminotransferase.

[Course of the early neonatal period and hormonal indicators in newborn infants from multiple pregnancies (twins)]. / Techenie rannego neonatal'nogo perioda i gormonal'nye pokazateli u novorozhdennykh, rodivshikhsia ot mnogoplodnoi beremennosti (dvoini).

Overall 22 neonates born due to plural pregnancy (twins, gestation 38-40 weeks) were examined for the clinical characteristics of the early neonatal period. Blood samples were analyzed, measurements were made of blood serum cortisol, immunoreactive insulin (IRI) and somatotropic hormone (STH). The findings were correlated to those obtained in controls, namely in 57 healthy neonates born due to single pregnancy. Alterations in the IRI content in twins turned out similar to those obtained by the authors in neonates with intrauterine hypotrophy. Cortisol was discovered to fall within the first day of life. The mean STH in twin children was much lower. The data obtained enable the neonate twins to be classified with the group at risk for development of hormonal abnormalities during the neonatal period.