Harnessing fluid-driven vesicles to pick up and drop off Janus particles.

Using dissipative particle dynamics (DPD) simulations, we model the interaction between nanoscopic lipid vesicles and Janus nanoparticles in the presence of an imposed flow. Both the vesicle and Janus nanoparticles are localized on a hydrophilic substrate and immersed in a hydrophilic solution. The fluid-driven vesicle successfully picks up Janus particles on the substrate and transports these particles as cargo along the surface. The vesicle can carry up to four particles as its payload. Hence, the vesicles can act as nanoscopic "vacuum cleaners", collecting nanoscopic debris localized on the floors of the fluidic devices. Importantly, these studies reveal how an imposed flow can facilitate the incorporation of nanoparticles into nanoscale vesicles. With the introduction of a "sticky" domain on the substrate, the vesicles can also robustly drop off and deposit the particles on the surface. The controlled pickup and delivery of nanoparticles via lipid vesicles can play an important step in the bottom-up assembly of these nanoparticles within small-scale fluidic devices.

Fibers with integrated mechanochemical switches: minimalistic design principles derived from fibronectin.

Inspired by molecular mechanisms that cells exploit to sense mechanical forces and convert them into biochemical signals, chemists dream of designing mechanochemical switches integrated into materials. Using the adhesion protein fibronectin, whose multiple repeats essentially display distinct molecular recognition motifs, we derived a computational model to explain how minimalistic designs of repeats translate into the mechanical characteristics of their fibrillar assemblies. The hierarchy of repeat-unfolding within fibrils is controlled not only by their relative mechanical stabilities, as found for single molecules, but also by the strength of cryptic interactions between adjacent molecules that become activated by stretching. The force-induced exposure of cryptic sites furthermore regulates the nonlinearity of stress-strain curves, the strain at which such fibers break, and the refolding kinetics and fraction of misfolded repeats. Gaining such computational insights at the mesoscale is important because translating protein-based concepts into novel polymer designs has proven difficult.

Using mesoscopic models to design strong and tough biomimetic polymer networks.

Using computational modeling, we investigate the mechanical properties of polymeric materials composed of coiled chains, or "globules", which encompass a folded secondary structure and are cross-linked by labile bonds to form a macroscopic network. In the presence of an applied force, the globules can unfold into linear chains and thereby dissipate energy as the network is deformed; the latter attribute can contribute to the toughness of the material. Our goal is to determine how to tailor the labile intra- and intermolecular bonds within the network to produce material exhibiting both toughness and strength. Herein, we use the lattice spring model (LSM) to simulate the globules and the cross-linked network. We also utilize our modified Hierarchical Bell model (MHBM) to simulate the rupture and reforming of N parallel bonds. By applying a tensile deformation, we demonstrate that the mechanical properties of the system are sensitive to the values of N(in) and N(out), the respective values of N for the intra- and intermolecular bonds. We find that the strength of the material is mainly controlled by the value of N(out), with the higher value of N(out) providing a stronger material. We also find that, if N(in) is smaller than N(out), the globules can unfold under the tensile load before the sample fractures and, in this manner, can increase the ductility of the sample. Our results provide effective strategies for exploiting relatively weak, labile interactions (e.g., hydrogen bonding or the thiol/disulfide exchange reaction) in both the intra- and intermolecular bonds to tailor the macroscopic performance of the materials.

Role of parallel reformable bonds in the self-healing of cross-linked nanogel particles.

We develop a hybrid computational approach to examine the mechanical properties and self-healing behavior of nanogel particles that are cross-linked by both stable and labile bonds. The individual nanogels are modeled via the lattice spring model (LSM), which is an effective method for probing the response of materials to mechanical deformation. The cross-links between the nanogels are simulated via the hierarchical Bell model (HBM), which allows us to capture the rupturing of multiple parallel bonds as the result of an applied force. Because the labile bonds are relatively reactive, they can reform after they have been ruptured. To incorporate the possibility of bonds reforming, we modify the HBM formalism and validate the modified HBM by considering a system of two surfaces, which are connected by multiple parallel bonds. We then use our hybrid HBM/LSM to simulate the behavior of the cross-linked nanogels under a tensile deformation. In these simulations, each labile linkage between the nanogels contains at most N parallel bonds. We vary the fraction of labile linkages and the value of N in these linkages to determine the optimal conditions for improving the robustness of the material. Although numerous parallel bonds within a linkage enhance the strength of the material, these bonds diminish the ductility and the ability of the material to undergo the structural rearrangements that are necessary for self-repair. For a relatively low fraction of labile bonds and N ≤ 4, however, we can significantly improve the strength of the material and preserve the self-healing properties. For instance, a sample with 30% labile linkages and N = 4 per linkage is roughly 200% stronger than a sample that is cross-linked solely by stable bonds and can still undergo self-repair in response to the tensile deformation. The results reveal how mechanical stress can lead not only to the appearance of cavities within the material but also to bond formation that "heals" these cavities and thus prevents the catastrophic failure of the material.