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1.
Braz. dent. sci ; 24(4, suppl 1): 1-8, 2021. tab, ilus
Article in English | LILACS, BBO - Dentistry | ID: biblio-1352634

ABSTRACT

Objective: Investigating osteopontin (OPN) level in gingival crevicular fluid (GCF) of patients affected by periodontitis with or without Type-2 diabetes mellitus (T2DM). The aim of this study is to explore the possibility of OPN to differentiate between periodontal health and disease. Material and Methods: A total number of 36 participants seeking periodontal treatment were recruited in this pilot study and divided into three study groups. Periodontitis [systemically healthy participants with periodontitis (probing pocket depth) PPD (probing pocket depth) ≥ 4mm], periodontitis and poorly controlled type 2 diabetes mellitus (), and control (systemically and periodontally healthy periodontium) groups. Plaque index (PI), gingival index (GI) and PPD were examined. OPN level was measured in the GCF and analysed, using Enzyme-Linked Immunosorbent assay. Results: PI and GI were significantly higher in T2DM with periodontitis compared to periodontitis and control groups. Both periodontitis and P-T2DM groups showed significant increase in the OPN levels compared to control group (p<0.001). PPD showed the only significant positive association with OPN (p<0.001) compared to other clinical parameters. The receiver operating characteristics curve analysis demonstrated that OPN had higher area under the curve value (AUC: 0.95) in periodontitis compared to P-T2DM patients (AUC: 0.86). Conclusion: In periodontitis groups, clinical parameters were equally deteriorated together with significant increase in the expression of OPN compared to control. Furthermore, GCF levels of OPN were sensitive and specific enough to discriminate between health and periodontitis even with T2DM. This could introduce OPN to be as a candidate diagnostic biomarker of periodontal disease. (AU)


Objetivo: Investigar o nível de osteopontina (OPN) no fluido gengival crevicular (GCF) de pacientes com periodontite com ou sem diabetes mellitus tipo 2 (T2DM). O objetivo deste estudo foi explorar a possibilidade da OPN diferenciar entre saúde e doença periodontal. Material e Métodos: No total, para este estudo piloto foram recrutados 36 participantes que estavam em busca de tratamento periodontal e divididos em três grupos de estudo: grupos periodontite [participantes sistemicamente saudáveis com periodontite (profundidade de sondagem) PPD ≥ 4 mm], grupo periodontite e Diabetes Mellitus tipo 2 mal controlada (P-T2DM) e grupo controle (saudáveis sistemicamente e periodontalmente). Índice de placa (PI), índice gengival (GI) e PPD foram examinados. O nível de OPN foi medido no GCF e analisado usando o ensaio ELISA (Enzyme-Linked Immuno Sorbent Assay). Resultados: PI e GI foram significativamente maiores no T2DM com periodontite em comparação aos grupos com periodontite e controle. Os grupos com periodontite e P-T2DM apresentaram aumento significativo nos níveis de OPN em comparação ao grupo controle (p <0,001). PPD mostrou a única associação positiva significativa com OPN (p <0,001) em comparação com outros parâmetros clínicos. A análise da curva de características operacionais do receptor demonstrou que OPN teve maior área sob o valor da curva (AUC: 0,95) na periodontite em comparação com pacientes com P-T2DM (AUC: 0,86). Conclusão: Nos grupos com periodontite, os parâmetros clínicos foram igualmente deteriorados juntamente com aumento significativo na expressão de OPN em comparação com o grupo controle. Além disso, os níveis de OPN no GCF foram sensíveis e específicos o suficiente para discernir entre saúde e periodontite, mesmo com T2DM. Isso poderia apresentar a OPN como um candidato a biomarcador diagnóstico de doença periodontal.(AU)


Subject(s)
Humans , Periodontitis , Bone Resorption , Diabetes Mellitus, Type 2 , Osteopontin
2.
J Indian Soc Periodontol ; 22(5): 390-394, 2018.
Article in English | MEDLINE | ID: mdl-30210186

ABSTRACT

BACKGROUND: Hormonal changes in women affect bone mineral density, especially during and postmenopausal years, which leads to susceptibility to osteoporosis which interfere with implantation. AIMS: This study aims to use cone-beam computed tomography (CBCT) viewer program to predict patients with osteoporosis which may decrease the success rate of implantation and to evaluate osteoporosis effect on the posterior mandible. SETTINGS AND DESIGN: This cross-sectional study consists of 60 Iraqi females who were divided into three groups: Group 1 consisted of 20 nonosteoporotic females aged 20-30 years as a control group, Group 2 consisted of 20 nonosteoporotic females aged 50 years and above, and Group 3 consisted of 20 osteoporotic females aged 50 years and above. MATERIALS AND METHODS: The posterior mandibular first molar area was examined for alveolar bone height and radiographic density (RD) using CBCT. STATISTICAL ANALYSIS USED: Statistical analysis was computer assisted using the Statistical Package for the Social Sciences (SPSS version 21). Interclass correlation coefficient was used for calibration. Normally distributed variables were assessed using one-way ANOVA, and Dunnett test with control and not normally distributed were assessed by Kruskal-Wallis test, and multiple Mann-Whitney U-test with Bonferroni adjustment. RESULTS: RD showed a significant difference between Group 2 and Group 3 (P = 0.000, MD = 158.554). On the other hand, alveolar bone height showed a significant difference between Group 1 and Group 2 (P = 0.039). CONCLUSIONS: RD in the posterior mandible first molar area is significantly affected in osteoporotic patients and it can be used as a predictor for the presence of osteoporosis using CBCT.

3.
J Indian Soc Periodontol ; 21(5): 376-379, 2017.
Article in English | MEDLINE | ID: mdl-29491583

ABSTRACT

BACKGROUND: Higher levels of receptor activator of nuclear factor kappa-ß ligand, i.e., RANKL, were reported among periodontitis patients compared with their healthy peers. This study aimed to measure the salivary level of RANKL among waterpipe smokers and to find the possible correlation between salivary level of RANKL and clinical periodontal parameters. MATERIALS AND METHODS: This study is a cross-sectional study involving 89 (49 waterpipe smokers and 40 nonsmokers) participants. The whole unstimulated saliva samples were collected for quantitative determination of RNAKL using a human RANKL enzyme-linked immunosorbent assay kit. Plaque index, gingival index, bleeding on probing, periodontal pocket depth (PPD), and clinical attachment level (CAL) were recorded for each participant. Mann-Whitney U-test was used to detect any difference between groups at P < 0.05. Spearman correlation coefficient test was used to test the association between variables. Linear regression was used to investigate the cause-and-effect relationship between the associated variables. RESULTS: In a comparison, RANKL, PPD, and CAL showed statistical differences (P < 0.05) between waterpipe smokers and nonsmokers. RANKL was found to be positively associated with CAL, and approximately 62.8% of CAL in this study sample could be explained by RANKL. The regression equation was CAL = 1.744 + 0.004 (RANKL). CONCLUSIONS: The salivary level of RANKL was positively related to CAL in this study sample.

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