ABSTRACT
The authors studied ++chemotaxis, phagocytosis and the activity of intracellular enzymes of leukocytes in the peripheral blood of 90 patients with reactive arthritis as compared to 23 patients with rheumatoid arthritis and 28 healthy individuals. Disorders of all these parameters were noted. They correlated with the specific features of the clinical course of the disease and its activity. In case of reactive arthritis the persistence of the infection and immunopathological disorders underlying chronic synovitis are attributable to the condition of nonspecific resistance.
Subject(s)
Arthritis, Rheumatoid/immunology , Arthritis/immunology , Chemotaxis, Leukocyte/immunology , Neutrophils/immunology , Phagocytosis/immunology , Adult , Alkaline Phosphatase/blood , Alkaline Phosphatase/deficiency , Arthritis/enzymology , Arthritis, Rheumatoid/enzymology , Enzyme Activation/physiology , Humans , In Vitro Techniques , Middle Aged , Neutrophils/enzymology , Peroxidase/bloodABSTRACT
A total of 46 patients with reactive arthritides and 20 patients with rheumatoid arthritis (RA) were examined, as compared with 20 normal persons, for the blood serum content of the products of catabolic breakdown of cell receptors--R proteins (according to inhibition of the hemagglutination reaction between human red blood cells and anti-R-serum) and for conventional parameters of phagocyte function of leukocytes. The content of R proteins in patients with reactive arthritis and RA was found to be increased, and the phagocytic activity was discovered to be lowered. The changes in the parameters indicated depended on the disease entity and the disease course. The possible pathophysiological importance of changes in the level of R proteins in arthritides is discussed.
