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1.
Int J Tuberc Lung Dis ; 22(12): 1450-1461, 2018 12 01.
Article in English | MEDLINE | ID: mdl-30606317

ABSTRACT

OBJECTIVE: To analyse 20 years of tuberculosis (TB) drug resistance surveillance, comparing conventional periodic random drug resistance surveys with continuous monitoring, in Damien Foundation-supported districts of Bangladesh. DESIGN: Retrospective study of data on TB drug resistance from five periodic surveys among newly registered patients vs. continuous monitoring of retreatment patients from 1996 to 2016. RESULTS: Periodic surveys and continuous monitoring showed similar trends in rifampicin (RMP) resistance; with all smear-positives registered as denominator, prevalence in new cases was found to be at approximately the same level as incidence in retreatment cases. Changes in trends observed using continuous monitoring preceded those detected in periodic surveys by a few years. The accurate interpretation of trend changes requires detailed knowledge of changes in treatment regimens, referral criteria, testing methods and operational factors. CONCLUSION: Low rates of resistance to RMP, isoniazid and the fluoroquinolones were maintained over the two decades, indicating excellent TB programme performance, including highly active standard first- and second-line treatment regimens. Continuous monitoring is feasible, but requires rigorous application of referral guidelines and data maintenance. Contrary to random surveys, continuous monitoring provides early indications of programme performance, essential for individual patient management, and is more efficient and cost-effective.


Subject(s)
Antitubercular Agents/pharmacology , Drug Resistance, Bacterial , Mycobacterium tuberculosis/drug effects , Rifampin/pharmacology , Tuberculosis/drug therapy , Bangladesh/epidemiology , Developing Countries , Female , Humans , Male , Microbial Sensitivity Tests , Molecular Epidemiology , Monitoring, Physiologic , Mycobacterium tuberculosis/isolation & purification , Population Surveillance , Program Evaluation , Recurrence , Retreatment , Retrospective Studies , Risk Assessment , Treatment Outcome , Tuberculosis/epidemiology
2.
Int J Tuberc Lung Dis ; 16(1): 70-5, 2012 Jan.
Article in English | MEDLINE | ID: mdl-22236849

ABSTRACT

BACKGROUND: Despite a well-functioning adult tuberculosis (TB) control programme, children with TB remain grossly under-detected in Bangladesh. It is conservatively estimated that annually around 21,000 children with TB go undetected, due to an almost exclusive focus on sputum smear-positive TB and the absence of training or guidelines in paediatric TB. OBJECTIVE: To double child TB detection by increasing general awareness and training of health care workers at microscopy centres supported by the Damien Foundation (DF) Bangladesh. METHODS: A cluster-randomised trial was carried out with provision of child TB guidelines, training and logistics support to staff of 18 microscopy centres, while 18 non-adjacent microscopy centres continued their usual practice and served as controls. Paediatric data on TB suspect referral and case detection were collected at baseline and during the intervention at both control and intervention sites. RESULTS: Child TB case detection increased in both intervention and control microscopy centres, but the increase was three times the baseline in the intervention centres (from 3.8% to 12%) in comparison to less than double the baseline in the control centres (from 4.3% to 7%, P = 0.001). CONCLUSION: Simple guidelines and training on child TB case detection, together with basic logistics support, can be integrated into the existing National TB Control Programme and improve service delivery to children in TB-endemic areas.


Subject(s)
Mass Screening , Mycobacterium tuberculosis/isolation & purification , Tuberculosis, Pulmonary/diagnosis , Age Factors , Attitude of Health Personnel , Awareness , Bangladesh/epidemiology , Child , Child, Preschool , Clinical Competence , Cluster Analysis , Community Health Workers/education , Female , Guideline Adherence , Health Knowledge, Attitudes, Practice , Humans , Male , Mass Screening/methods , Microscopy , Practice Guidelines as Topic , Predictive Value of Tests , Program Evaluation , Referral and Consultation , Sputum/microbiology , Tuberculosis, Pulmonary/epidemiology , Tuberculosis, Pulmonary/microbiology
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