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Biochemistry (Mosc) ; 83(4): 402-410, 2018 Apr.
Article in English | MEDLINE | ID: mdl-29626927

ABSTRACT

Chromosomal translocations have long been known for their association with malignant transformation, particularly in hematopoietic disorders such as B-cell lymphomas. In addition to the physiological process of maturation, which creates double strand breaks in immunoglobulin gene loci, environmental factors including the Epstein-Barr and human immunodeficiency viruses, malaria-causing parasites (Plasmodium falciparum), and plant components (Euphorbia tirucalli latex) can trigger a reorganization of the nuclear architecture and DNA damage that together will facilitate the occurrence of deleterious chromosomal rearrangements.


Subject(s)
B-Lymphocytes/metabolism , B-Lymphocytes/pathology , Cell Transformation, Neoplastic , Translocation, Genetic/genetics , DNA Damage , Euphorbia/metabolism , HIV/metabolism , Herpesvirus 4, Human/metabolism , Humans , Plasmodium falciparum/metabolism
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