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1.
BMC Pediatr ; 19(1): 216, 2019 07 02.
Article in English | MEDLINE | ID: mdl-31266444

ABSTRACT

BACKGROUND: Propranolol hydrochloride is the first-line agent recommended for the treatment of infantile hemangiomas (IH). Serious adverse effects of propranolol therapy for hemangiomas are infrequent. CASE PRESENTATION: We report a case presented in deep hypoglycemic coma during his treatment with propranolol for IH. Through our case report and the review of the literature, we aimed to underline the importance of recognizing adverse effects during propranolol therapy. Although propranolol has a long history of safe and effective use in infants and children, pediatricians should be aware that life-threatening adverse effects can happen during propranolol therapy for IH. CONCLUSION: Early identification of these adverse effects can be of great importance for patient management and prognosis. It must certainly be noted that not just early identification among doctors, but education for parents is crucial.


Subject(s)
Adrenergic beta-Antagonists/adverse effects , Coma/chemically induced , Hemangioma/drug therapy , Hypoglycemia/chemically induced , Propranolol/adverse effects , Administration, Oral , Adrenergic beta-Antagonists/administration & dosage , Glucose/administration & dosage , Humans , Hypoglycemia/therapy , Infant , Male , Propranolol/administration & dosage
3.
Open Access Maced J Med Sci ; 3(3): 443-6, 2015 Sep 15.
Article in English | MEDLINE | ID: mdl-27275268

ABSTRACT

BACKGROUND: Acetaminophen is a drug widely used in children because of its safety and efficacy. Although the risk of its toxicity is lower in children such reactions occur in pediatric patients from intentional overdoses and less frequently attributable to unintended inappropriate dosing. The aim of reporting this case is to attract the attention to the risk of the acetaminophen toxicity when administered in high doses. CASE PRESENTATION: We report here a 5 year old girl who developed fulminate liver failure with renal impairment and acute pancreatitis, as a result of acetaminophen toxicity caused from unintentional repeated supratherapeutic ingestion, with a total administered dose of 4800 mg in three consecutive days, 1600 mg/day, approximately 90 mg/kg/day. The blood level of acetaminophen after 10 hours of the last administered dose was 32 mg/l. The patient presented with high fever, jaundice, lethargic, agitating with abdominal pain accompanied by encephalopathy. The liver function test revealed with high level of alanine aminotransferase 5794 UI/l and aspartate aminotransferase 6000 UI/l. Early initiation of oral N-acetylcysteine (NAC) after biochemical evidence of liver toxicity was beneficial with rapid improvement of liver enzymes, hepatic function and encephalopathy. During the course of the illness the child developed acute pancreatitis with hyperamylasemia 255 UI/L and hyperlypasemia 514 UI/L. Patient totally recovered within 29 days. CONCLUSION: Healthcare providers should considered probable acetaminophen toxicity in any child who has received the drug and presented with liver failure. When there is a high index of suspicion of acetaminophen toxicity NAC should be initiated and continued until there are no signs of hepatic dysfunction.

4.
Ital J Pediatr ; 40: 35, 2014 Apr 04.
Article in English | MEDLINE | ID: mdl-24708654

ABSTRACT

Idiopathic pulmonary hemosiderosis is a rare disorder that can occur at any age and is characterized by the triad of hemoptysis, iron deficiency anemia and diffuse pulmonary infiltrates. The clinical course is exceedingly variable especially in children and a substantial proportion of this age group is undiagnosed. It is probably due to the fact that iron deficiency anemia may be the first and the only manifestation of IPH, preceding other symptoms and signs by several months and IPH is not considered as a rare cause of anemia, unless the typical triad is present. We present a case of IPH in a 13-year-old girl, treated for several months with persistent iron deficiency anemia, without response to therapy.


Subject(s)
Anemia, Iron-Deficiency/complications , Hemoglobins/metabolism , Hemosiderosis/diagnosis , Lung Diseases/diagnosis , Adolescent , Anemia, Iron-Deficiency/blood , Anemia, Iron-Deficiency/diagnosis , Diagnosis, Differential , Erythrocyte Count , Erythrocyte Indices , Female , Follow-Up Studies , Hemosiderosis/blood , Hemosiderosis/etiology , Humans , Iron/blood , Lung Diseases/blood , Lung Diseases/etiology , Tomography, X-Ray Computed , Hemosiderosis, Pulmonary
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