ABSTRACT
The present study aims to investigate the physicochemical and the structural features of polysaccharide isolated from the red marine macro alga Chondrus canaliculatus (C.C.P) using FT-IR, gel filtration high-pressure chromatograph, HPLC-FID and solid state 13C NMR analysis. C.C.P was even more tested in vitro for its potential antioxidant properties and in vivo for its hemato-nephroprotective effects against fungicide - maneb (MB) - induced toxicity. Animals treated for 20â¯days were allocated into six groups per six rats each: group 1 served as vehicle control, group 2 received MB, group 3 received MBâ¯+â¯C.C.P (100â¯mg/kg), group 4â¯MBâ¯+â¯C.C.P (200â¯mg/kg), group 5 and 6 used as a positive control groups receiving only C.C.P; one 100 and the other 200â¯mg/kg, respectively. After MB injection, our data displayed a significant disruption in all hematological parameters associated with clear signs of nephrotoxicity. However, co-treatment with C.C.P at two graded doses led to an effective healing process against MB's hematological, biochemical, and histological kidney's oxidative injuries. In summary, our data suggest that C.C.P could be a prospective potent antioxidant, nephro and hemato-protective agent.