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1.
Nat Prod Res ; 35(5): 853-857, 2021 Mar.
Article in English | MEDLINE | ID: mdl-31090448

ABSTRACT

Chemical investigation of the extracts of the fruits from Campomanesia xanthocarpa resulted in the isolation of six known compounds identified by NMR and comparison with literature data (2',4'-dihydroxy-5'-methyl-6'-methoxychalcone (1), 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone (2), 2'-hydroxy-3'-methyl-4',6'-dimethoxychalcone (3), 2',6'-dihydroxy-3'-methyl-4'-methoxychalcone (4), 5-hydroxy-7-methoxy-8-methylflavanone (5) and 7-hydroxy-5-methoxy-6-methylflavanone (6)). The considerable antioxidant capacity of the extracts was demonstrated by ORAC-FL and DPPH tests. The antiproliferative assay of the extracts and 5 was done in vitro, against many different cancer cell lines besides a healthy one. The extracts presented low cytotoxicity and the substance demonstrated promising results against all the cancer cell lines tested, with IC50 values ranging from 4.75 to 45.81 µmol L-1. The in vitro trypanocidal activity was evaluated against the epimastigote form of the Y strain of Trypanosoma cruzi and an improvement in the activity of the substances 2 (221.81 µmol L-1) and 5 (61.87 µmol L-1) was observed regarding the values obtained for the extracts.


Subject(s)
Antioxidants/pharmacology , Antiprotozoal Agents/pharmacology , Fruit/chemistry , Myrtaceae/chemistry , Trypanosoma/drug effects , Antioxidants/chemistry , Antioxidants/isolation & purification , Antiprotozoal Agents/chemistry , Antiprotozoal Agents/isolation & purification , Cell Line, Tumor , Cell Proliferation/drug effects , Humans , Plant Extracts/chemistry
2.
Inflammation ; 39(4): 1462-8, 2016 Aug.
Article in English | MEDLINE | ID: mdl-27271512

ABSTRACT

Campomanesia xanthocarpa (Myrtaceae) is used in Brazilian traditional medicine against fever, diabetes, hypercholesteremic, obesity, and urinary diseases. In the present study, the compounds 2',6'-dihydroxy-3'-methyl-4'-metoxychalcone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone were identified for the first time in leaves of the C. xanthocarpa. These compounds and the hydroethanolic extract (HECX) significantly inhibited paw edema and reduced both leukocyte migration and the leakage of protein into the pleural cavity. No toxicity was detected by HECX in an acute toxicity test.


Subject(s)
Anti-Inflammatory Agents/pharmacology , Chalcones/pharmacology , Myrtaceae/chemistry , Animals , Anti-Inflammatory Agents/isolation & purification , Anti-Inflammatory Agents/therapeutic use , Brazil , Cell Movement/drug effects , Chalcones/isolation & purification , Chalcones/therapeutic use , Chalcones/toxicity , Edema/drug therapy , Leukocytes/cytology , Medicine, Traditional/methods , Mice , Plant Extracts/therapeutic use , Plant Leaves/chemistry , Pleural Cavity/metabolism , Proteins/metabolism
3.
J Med Food ; 13(5): 1273-6, 2010 Oct.
Article in English | MEDLINE | ID: mdl-20828322

ABSTRACT

The antimicrobial activity of the hexanic extracts and fractions of fruits of Campomanesia pubescens pubescens (D.C) O. Berg and Campomanesia adamantium (Cambess.) O. Berg were assayed against six microorganisms. The hexanic extracts of C. pubescens and C. adamantium fruits were also investigated in their composition by gas chromatography-mass spectrometry and high-performance liquid chromatography with diode array detection. The results of this study showed the presence of 34 volatile compounds and flavonoids in the hexanic extract of C. pubescens and 33 volatile compounds and flavonoids in the hexanic extract of C. adamantium.


Subject(s)
Anti-Infective Agents/pharmacology , Fruit/chemistry , Myrtaceae/chemistry , Plant Extracts/pharmacology , Chromatography, High Pressure Liquid , Flavonoids/analysis , Gas Chromatography-Mass Spectrometry , Plant Extracts/chemistry , Volatile Organic Compounds/analysis
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