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Bioorg Med Chem Lett
; 18(18): 4952-5, 2008 Sep 15.
Article
in English
| MEDLINE
| ID: mdl-18755587
ABSTRACT
Evaluation of hit chemotypes from high throughput screening identified a novel series of 2,4-disubstituted thieno[2,3-c]pyridines as COT kinase inhibitors. Structural modifications exploring SAR at the 2- and 4-positions resulting in inhibitors with improved enzyme potency and cellular activity are disclosed.