[The mechanism of the transport of organophosphorus compounds across the histo-hematic barriers]. / K voprosu o mekhanizme transorta fosfororganicheskikh soedinenii cherez gisto-gematicheskie bar'ery.

It was demonstrated in experiments on mice [correction of rats] that the transport of organophosphorus compounds (OPC) through membranes of the histohematic barriers (HHB) of the organism occurs by means of diffusion. The rate of this process depends on the interaction of OPC with the specific sites of binding with the tissues, among which the enzyme carboxylesterase plays an important part. It is suggested that both the rate and direction of OPC diffusion are determined by the relationship between the values of affinity of the ligands for the sites of their specific binding found on both sides of the HHB.