[Biochemical mechanisms of neurotoxic reactions to antibacterial preparations in patients with pulmonary tuberculosis]. / Biokhimicheskie mekhanizmy neirotoksicheskikh reaktsii na antibakterial'nye preparaty u bol'nykh tuberkulezom legkikh.

Examination comprising the electrophysiologic method and study of the biochemical parameters of the antioxidant/lipid peroxidation system and metabolism of biologic amines in 163 patients with infiltrative pulmonary tuberculosis has revealed a clear interaction existing between the functional changes of the CNS state, the state of antioxidative defense (alpha-tocopherol) and serotonin. This allows an assumption that the antioxidant/lipid peroxidation system and serotoninergic system actively participate in the pathogenesis of development of neurotoxic reactions to antibacterial preparations in the clinical picture of tuberculosis.

[The use of antioxidants in the complex therapy of patients with infiltrating pulmonary tuberculosis]. / Primenenie antioksidantov v kompleksnom lechenii bol'nykh infil'trativnym tuberkulezom legkikh.

Clinical and laboratory investigations examined the possibility of a lower load of antibacterial drugs (ABD) in combination with the two antioxidants, alpha-tocopherol and sodium thiosulfate, in combined therapy of patients with infiltrative pulmonary tuberculosis. Higher efficacy of two ABDs supplemented by two antioxidants than three or more ABDs was evidenced by a shorter period of sputum negativity (1.6 +/- 0.26 and 2.7 +/- 0.27 months; p less than 0.01) and higher rates of cavity closure (95.6 +/- 4.3 and 63.2 +/- 6.7%; p less than 0.05).

[Functional disorders of the central nervous system in patients with pulmonary tuberculosis]. / Narusheniia funktsional'nogo sostoianiia tsentral'noi nervnoi sistemy u bol'nykh tuberkulezom legkikh.

Two groups of pulmonary tuberculosis patients were followed up to reveal the relation between the lipid peroxidation (LPO) processes and the function of the central nervous system (CNS) in pulmonary tuberculosis. Group 1 (n = 76) included subjects with normal baseline electroencephalographic findings; group 2 (n = 41) consisted of those with profound changes in the electroencephalogram. The findings of LPO processes were assessed by the blood levels of malonic dialdehyde and alpha-tocopherol. Group 2 showed a direct relationship between the progression of neurotic symptoms and the abnormal changes in the values of LPO processes. It is concluded that it is expedient to use antioxidants in the combined treatment of pulmonary tuberculosis patients to eliminate the baseline CNS changes caused by the specific process.