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Atherosclerosis ; 161(1): 199-207, 2002 Mar.
Article in English | MEDLINE | ID: mdl-11882333

ABSTRACT

Tocotrienols are effective in lowering serum total and LDL-cholesterol levels by inhibiting the hepatic enzymic activity of beta-hydroxy-beta-methylglutaryl coenzymeA (HMG-CoA) reductase through the post-transcriptional mechanism. alpha-Tocopherol, however, has an opposite effect (induces) on this enzyme activity. Since tocotrienols are also converted to tocopherols in vivo, it is necessary not to exceed a certain dose, as this would be counter-productive. The present study demonstrates the effects of various doses of a tocotrienol-rich fraction (TRF25) of stabilized and heated rice bran in hypercholesterolemic human subjects on serum lipid parameters. Ninety (18/group) hypercholesterolemic human subjects participated in this study, which comprised three phases of 35 days each. The subjects were initially placed on the American Heart Association (AHA) Step-1 diet and the effects noted. They were then administered 25, 50, 100, and 200 mg/day of TRF25 while on the restricted (AHA) diet. The results show that a dose of 100 mg/day of TRF25 produce maximum decreases of 20, 25, 14 (P<0.05) and 12%, respectively, in serum total cholesterol, LDL-cholesterol, apolipoprotein B and triglycerides compared with the baseline values, suggesting that a dose of 100 mg/day TRF25 plus AHA Step-1 diet may be the optimal dose for controlling the risk of coronary heart disease in hypercholesterolemic human subjects.


Subject(s)
Antioxidants/therapeutic use , Cholesterol/blood , Hypercholesterolemia/drug therapy , Oryza , Plant Extracts/therapeutic use , Tocotrienols/therapeutic use , Adult , Antioxidants/administration & dosage , Apolipoprotein A-I/blood , Apolipoproteins B/blood , Cholesterol, HDL/blood , Cholesterol, LDL/blood , Coronary Disease/prevention & control , Dose-Response Relationship, Drug , Female , Hot Temperature , Humans , Hypercholesterolemia/diet therapy , Male , Middle Aged , Plant Extracts/administration & dosage , Tocotrienols/administration & dosage , Triglycerides/blood
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