[Dental gel Cholisal at the stage of conservative treatment of inflammatory periodontal diseases]. / Klinicheskaya effektivnost' konservativnogo lecheniya patsientov s khronicheskim generalizovannym parodontitom s primeneniem gelya Kholisal.

PURPOSE OF THE STUDY: To study the effectiveness of the drug Cholisal as part of the conservative treatment of chronic periodontitis. MATERIAL AND METHODS: We selected 100 patients aged 35 to 65 years of both sexes with a diagnosis of moderate chronic periodontitis in the acute stage with a periodontal pocket depth of 3.5-5 mm. Depending on the tactics of conservative treatment of periodontitis, patients were divided into two groups of 50 people. In the main group, Cholisal dental gel was used as part of complex conservative treatment, and in the control group, Metrogil-denta gel was used. To assess the effectiveness of treatment, a dental examination of patients was carried out with an index assessment of the condition of periodontal tissues and a biochemical analysis of the content of arachidonic acid and prostaglandin E2 in gingival blood, comparing the indicators before treatment and 14 days after the start of treatment. RESULTS: When the drug Cholisal was included in complex treatment, 14 days from the start of treatment, patients experienced a statistically significant decrease in the depth of periodontal pockets from 4.7±0.32 mm to 3.6±0.19, and the Green-Vermillion hygiene index by 60.7%, Silness-Loe plaque index by 73.1%, PMA index by 68.8%, Muhlemann-Cowell bleeding index by 68.0% (p<0.001 compared to baseline). When Metrogil-denta gel was used in complex therapy, the effectiveness of treatment was lower: the depth of periodontal pockets did not change significantly (from 4.5±0.22 mm to 4.2±0.17 mm, p>0.05), reduction in the hygiene index Green-Vermillion was 51.9%, Silness-Loe plaque index - 64.0%, PMA index - 43.7%, Muhlemann-Cowell bleeding index - 45.8% (p<0.001 compared to baseline, p<0.001 compared to the main group). A laboratory study showed that in patients of the main group, after completing a course of conservative treatment, the content of biomarkers of inflammation significantly decreased compared to the initial level (p<0.05), while in patients of the control group the content of arachidonic acid and prostaglandin E2 in the gingival blood during the study period did not change significantly (p>0.05 compared to the initial level). CONCLUSIONS: The use of the drug Cholisal in the conservative treatment of chronic periodontitis has demonstrated more pronounced positive dynamics of clinical and biochemical parameters compared to traditional therapy, which suggests its high effectiveness.

[Influence of gender, age and metabolic factors on the course of chronic generalized periodontitis in patients with metabolic syndrome]. / Vliianie gendernykh, vozrastnykh i metabolicheskikh faktorov na techenie khronicheskogo generalizovannogo parodontita u patsientov s metabolicheskim sindromom.

In a study of 537 patients with chronic generalized periodontitis and metabolic syndrome, depending on gender, age and metabolic factors, it was found that with increasing of body mass index (BMI) symptoms of chronic generalized periodontitis is becoming more unfavorable, there is a close positive relationship between the severity of chronic generalized periodontitis and BMI. Patients' with BMI ≥40 kg/m2 in 80% of cases, periodontitis was characterized by severe course. It was found that the gender of the patient becomes relevant only with correlation of age and BMI. It was proved that for the most accurate prognosis of chronic generalized periodontitis, patient's sex, age and BMI should be taken into consideration. The developed model for predicting the course of chronic generalized periodontitis depending on the sex, age and metabolic factors of a particular patient, allows to monitor the dynamics of the disease in time.

[The effectiveness of com bined treatment with simbiotiks and antioxidants in patients with periodontal disease and metabolic syndrome].

The article discusses the pathophysiological mechanisms of the relationship between inflammatory periodontal diseases and metabolic syndrome (MS). Clinical and biochemical assessment of the dynamics of indicators of lipid blood profile, carbohydrate metabolism and oxidative stress has been conducted in patients with periodontal disease and MS. We examined and treated 73 patients aged from 35 to 55 years with clinical and biochemical features of the MS (body mass index (BMI) >25 kg/m2, abdominal type of obesity, impaired glucose tolerance and atherogenic dyslipidemia). According to the data obtained, the inclusion of probiotics and antioxidant in the complex therapy on the background of the reduced low-carbohydrate diet and increased physical activity in MS patients contributed to the correction of atherogenic blood plasma indexes, normalization of carbohydrate metabolism, cupping effects of oxidative stress, improvement of reparative processes in periodontal tissues, more pronounced than in patients receiving standard treatment (control). After treatment at 24 weeks BMI decrease by 8.6% (from 32.7±0.8 to 29.9±0.6 kg/m2) mainly due to the reduction in fat mass (by 23%) has been observed in the whole group of patients with MS. The HOMA IR index decreased in patients of the main group by 31.8% while in the control group - only by 8.5% (p<0.001), fasting immunoreactive insulin level - by 13 vs 4.5% (p<0.001), insulin C-peptide level - by 36.8 vs 21.6% (p<0.01), glycated hemoglobin - by 13.0% versus 4.7% (p<0.01), malondialdehyde - by 47.8 vs 25.8% (p<0.01). Levels of total cholesterol, triglycerides and low-density lipoproteins decreased in patients of the main group by 13.0; 30.8 and 19.0%, respectively, while in the control group the decrease was lower and amounted to 4.7; 25.0 and 14.6% (p<0.05-0.01).