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1.
Am J Cardiol ; 162: 73-79, 2022 01 01.
Article in English | MEDLINE | ID: mdl-34728062

ABSTRACT

The clinical efficacy of the inhibitors of the renin-angiotensin-aldosterone system (RAAS) as an upstream therapy for atrial fibrillation (AF) prevention is controversial. No study has itemized so far the role of RAAS inhibitors in AF prevention after atrial flutter (AFL) ablation. This trial aims to investigate the effect of ramipril compared with placebo on AF occurrence in patients hospitalized for AFL ablation without structural heart disease. The Prevention of Atrial Fibrillation by Inhibition Conversion Enzyme (ICE) After Radiofrequency Ablation of Atrial Flutter (PREFACE) trial was a prospective, multicenter, randomized, double-blind, double-dummy trial depicting the AF occurrence during a 12-month follow-up as the primary end point. A total of 198 patients hospitalized for AFL ablation were enrolled in the trial and randomized to placebo or ramipril 5 mg/day. Patients were followed up during 1 year after AFL ablation using 1-week Holter electrocardiogram at 3, 6, 9, and 12 months. The intention-to-treat population encompassed 97 patients in the ramipril group and 101 patients in the placebo group. The primary end point, such as AF occurrence during the 1-year follow-up, was not different between the 2 groups (p = 0.96). Secondary end points, including the occurrence of supraventricular arrhythmia (p = 0.50), heart failure, stroke, and death, were not different between the 2 groups. Safety outcome parameters, including serious adverse events leading to treatment disruption (p = 0.10), hypotension, impairment of renal function, and elevated serum potassium level, also were not different between the 2 groups. In conclusion, RAAS inhibition using ramipril does not reduce AF occurrence in patients facing AFL ablation during the 1-year follow-up.


Subject(s)
Angiotensin-Converting Enzyme Inhibitors/therapeutic use , Atrial Fibrillation/prevention & control , Atrial Flutter/drug therapy , Atrial Flutter/surgery , Catheter Ablation , Ramipril/therapeutic use , Aged , Atrial Fibrillation/diagnosis , Double-Blind Method , Electrocardiography, Ambulatory , Female , Follow-Up Studies , Hospitalization , Humans , Kaplan-Meier Estimate , Male , Middle Aged , Prospective Studies , Recurrence , Treatment Outcome
2.
Arch Cardiovasc Dis ; 107(1): 42-7, 2014 Jan.
Article in English | MEDLINE | ID: mdl-24373622

ABSTRACT

UNLABELLED: Vasospastic angina is a frequent and well-recognized pathology with a high risk of life-threatening ventricular arrhythmias and sudden cardiac death. The diagnosis of vasospastic angina requires the combination of clinical and electrocardiographic variables and the results of provocation tests, such as ergonovine administration. Smoking cessation is the first step in the management of vasospastic angina. Optimal medical treatment using calcium-channel blockers and/or nitrate derivatives can provide protection, but life-threatening ventricular arrhythmias may occur despite optimal medical treatment and several years after the start of treatment. In this review, we evaluate the role of implantable defibrillators as a complement to optimal medical management in patients with life-threatening ventricular arrhythmias due to vasospastic angina; this role is not well characterized in the literature or guidelines. We discuss the role of implantable defibrillators in secondary prevention in light of three recent cases managed in our departments and a review of the literature. An implantable defibrillator was implanted in two of the three cases of vasospastic angina with ventricular arrhythmias that we managed. We considered secondary prevention by implantable defibrillator to be justified even in the absence of any obvious risk factor. Ventricular arrhythmias recurred during implantable defibrillator follow-up in the two patients implanted. CONCLUSION: In patients with life-threatening ventricular arrhythmias due to vasospastic angina, an implantable defibrillator should be considered because of the risk of recurrence despite optimal medical management.


Subject(s)
Angina Pectoris/therapy , Arrhythmias, Cardiac/prevention & control , Coronary Vasospasm/therapy , Death, Sudden, Cardiac/prevention & control , Defibrillators, Implantable , Electric Countershock/instrumentation , Angina Pectoris/diagnosis , Angina Pectoris/mortality , Angina Pectoris/physiopathology , Arrhythmias, Cardiac/diagnosis , Arrhythmias, Cardiac/mortality , Arrhythmias, Cardiac/physiopathology , Coronary Angiography , Coronary Vasospasm/diagnosis , Coronary Vasospasm/mortality , Coronary Vasospasm/physiopathology , Death, Sudden, Cardiac/etiology , Electrocardiography , Female , Humans , Male , Middle Aged , Patient Selection , Predictive Value of Tests , Prosthesis Design , Risk Assessment , Risk Factors , Smoking/adverse effects , Smoking Cessation , Smoking Prevention , Tomography, Optical Coherence , Treatment Outcome
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