ABSTRACT
OBJECTIVE: Timed neuropsychological tests do not take into account physical impairment during scoring procedures. Dysarthria and upper limb impairment can be easily measured with the PATA rate test (PRT) and the nine-hole pegboard test (9HPT). We recently validated a normalization method for timed neuropsychological tests using the PRT and 9HPT (p9NORM). We now validate the p9NORM in Parkinson's disease (Yarnall et al. Neurology 82(4):308-316; 2014) and multiple system atrophy (MSA). METHODS: We enrolled twenty-six patients with PD, eighteen patients with MSA, and fifteen healthy controls (HC). p9NORM was applied to patients with abnormal PRT and/or 9HPT. All subjects were tested with a comprehensive neuropsychological battery. RESULTS: No differences emerged in demographics across groups: (PD: mean age ± SD 66 ± 8; education 9 ± 4 years; MSA: age 60 ± 8; education 10 ± 4 years; HC: age 61 ± 12; education 9 ± 4 years). In MSA patients, the scores on the trail making test (TMT-A p = 0.003; TMT-B p = 0.018), attentional matrices (AM; p = 0.042), and symbol digit modalities test (SDMT p = 0.027) significantly differed following application of p9NORM. In PD patients, the TMT-A (p < 0.001), TMT-B (p = 0.001), and AM (p = 0.001) differed after correction. PD and MSA showed cognitive impairment relative to HC performance. When comparing MSA with PD, the SDMT, AM, and fluencies were similar. TMT-A and -B raw scores were different between groups (p = 0.006; p = 0.034), but these differences lost significance after p9NORM corrections (p = 0.100; p = 0.186). CONCLUSIONS: We confirm that the p9NORM can be successfully used in both PD and MSA patients, as it mitigates the impact of disability on timed tests, resulting in a more accurate analysis of cognitive domains.
Subject(s)
Cognitive Dysfunction , Multiple System Atrophy , Parkinson Disease , Aged , Cognitive Dysfunction/diagnosis , Cognitive Dysfunction/etiology , Humans , Middle Aged , Multiple System Atrophy/complications , Multiple System Atrophy/diagnosis , Neuropsychological Tests , Parkinson Disease/complications , Parkinson Disease/diagnosis , Trail Making TestABSTRACT
BACKGROUND: During neurological evaluation, dysarthria is not rated using quantitative measures, but rather using a qualitative approach. OBJECTIVE: Aim of our study was to validate and acquire normative values for the PATA Rate Task (PRT), a quantitative test used to measure the severity of dysarthria. METHODS: For the PRT probands are invited to repeat the syllables "PA-TA" as quickly as possible during a 10-s interval. The score consists in the number of correct repetition of both syllables. RESULTS: We enrolled 232 healthy controls (118 males, 114 females), mean and standard deviation of the PRT was 28.84 ± 6.6 (range 14-52). The PRT showed good inter-rater reliability (R = 0.783; p < 0.001), as well as test-retest reliability (R = 0.927; p < 0.001), and intra-rater reliability (R = 0.888; p < 0.001). Higher age correlated with lower scores (R = - 0.368; p < 0.001). CONCLUSIONS: The PRT showed good reliability and could be easily added to the evaluation of movement disorders where a speech evaluation is essential.
