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Biochim Biophys Acta Mol Cell Res ; 1869(5): 119237, 2022 05.
Article in English | MEDLINE | ID: mdl-35150807

ABSTRACT

Nucleotides are released from all cells through regulated pathways or as a result of plasma membrane damage or cell death. Outside the cell, nucleotides act as signalling molecules triggering multiple responses via specific plasma membrane receptors of the P2 family. In the nervous system, purinergic signalling has a key function in neurotransmission. Outside the nervous system, purinergic signalling is one of the major modulators of basal tissue homeostasis, while its dysregulation contributes to the pathogenesis of various disease, including inflammation and cancer. Pre-clinical and clinical evidence shows that selective P2 agonists or antagonists are effective treatments for many pathologies, thus highlighting the relevance of extracellular nucleotides and P2 receptors as therapeutic targets.


Subject(s)
Nucleotides/metabolism , Signal Transduction , Animals , Cardiovascular Diseases/metabolism , Cardiovascular Diseases/pathology , Cell Membrane/metabolism , Humans , Lung Diseases/metabolism , Lung Diseases/pathology , Neoplasms/metabolism , Neoplasms/pathology , Nucleotides/analysis , Receptors, Purinergic P2X/metabolism , Receptors, Purinergic P2Y/metabolism
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