Expression of metallothionein I/II and Ki-67 antigen in various histological types of basal cell carcinoma.

Basal cell carcinoma (BCC) is the most frequent skin cancer, with many different histological subtypes. Recent studies have investigated the expression of proliferative markers, but little is known about the expression of metallothioneins (MT) in different histological subtypes of this cancer and their impact on proliferation intensity in BCC. In this study, we examined MT-I/II expression by immunohistochemistry in 58 different histological subtypes of BCC (38 nodular, six adenoid, eight infiltrative, and six metatypic cases) and correlated its expression with tumor size and Ki-67 proliferation rate. Statistical analysis revealed no significant differences in the expression of studied markers in regard to the histological subtype. A positive correlation between MT and Ki-67 expression was observed for all the studied cases (r = 0.26; p = 0.049), but was even stronger in the metatypic subtype of BCC (r = 0.85; p = 0.033). MT and Ki-67 expression did not correlate with tumor size. In conclusion, it seems that metallothioneins may have an impact on the proliferation rate of BCC,but further studies are required to determine whether MT may be a risk factor of recurrences.

Analysis of the impact of external factors on the occurrence of morphological lesions in cases of death from hypothermia.

The objective of this study was to determine the prevalence of macroscopic morphological lesions typical of death from hypothermia and to show their correlation with such factors as blood alcohol level, air temperature, age and number of layers of clothing. The analysis was performed based on protocols of autopsies performed in the years 1995-2009. The sample comprised 124 persons with a diagnosis of death from hypothermia. The results showed no correlation between the number of gastric erosions and the level of alcohol in blood or urine. However, an association was demonstrated between the presence of erosions and the number of layers of clothing. A positive correlation may indicate an increased sensation of cold by such persons and the resultant more intense vascular,constriction response occurring in the gastric mucosa.

[MORS--the stationary model centre of sociopsychiatric rehabilitation for youths--the program and evaluation]. / Modelowy Osrodek Rehabilitacji Socjopsychiatrycznej dla mlodziezy--MORS--program i badania ewaluacyjne.

INTRODUCTION: The psychosocial consequences of psychosis in the youth are educational negligence's, poor peer relations and difficulties in achieving life independency. MORS--the Stationary Model Centre of Sociopsychiatric Rehabilitation was created for overcoming these problems. AIM: To present the programme of rehabilitation and its effects in MORS. METHOD: The evaluation was performed in 18 of the 26 young persons being admitted to MORS in the years 2006-2008. Structured Questionnaires of past history for the staff and clients, the SOC-29 and KIDscreen -52 scales were used. RESULTS: A significant number of young people from incomplete families, and/or families burdened with parental mental health problems was noticeable. The best effects were achieved in compensating for educational negligence's, and improving the social and life skills. The self estimation of health and life satisfaction was lower in the youth clients on discharge from MORS than in the general population. CONCLUSIONS: According to retrospective evaluation, the stationary programme of psychosocial rehabilitation in MORS seems to be effective in youths with psychotic disorders and difficulties in social functioning. Further development, and prospective evaluation of that programme would be valuable. Social support in local communities for the youth being discharged from MORS is needed.