Intraoperative, imaging and pathological features in spinal cord vasculitis.

The surgical intraoperative findings in spinal cord vasculitis have not been previously described. The imaging appearances can mimic intramedullary spinal cord tumours. We present a patient with spinal cord vasculitis and mixed intraoperative findings of spinal vascular lesion and intramedullary tumour. Based on the absence of a confirmatory intraoperative smear, vessel obliteration and tumour debulking was avoided, preventing a catastrophic surgical complication. The limited literature and management options are also reviewed.

Amyloid in neurosurgical and neurological practice.

The amyloidoses are a diverse group of diseases characterized by the deposition of specific proteins with distinct affinity to the dye Congo red, collectively called amyloid. The amyloidogenic proteins have acquired an abnormal, highly ordered, beta-pleated sheet configuration with a propensity to self-aggregate. The amyloid may be distributed in different organs with a remarkable diversity. Two broad categories of amyloidoses are recognised: The systemic (consisting of the primary or light chain form, the secondary or reactive form and the familial or hereditary form) and the localised that target specific organs. A tropism of amyloid proteins to the neural tissue produces certain patterns of central nervous system diseases: cerebral amyloid angiopathy, a substrate of spontaneous intracerebral haemorrhage; mature neuritic plaques found in Alzheimer disease and a subset of prion diseases; a topographically restricted accumulation of extracellular proteins giving rise to tumour-mimicking masses, the amyloidomas; and finally, spinal extradural amyloid collections that occasionally are found in the context of rheumatoid arthritis. In this review article we present original illustrative cases of amyloid diseases of the central nervous system that may be encountered in neurosurgical and neurological practice. Molecular aspects and clinical management problems are discussed.

Neurosurgical treatment of Nelson's syndrome.

Total bilateral adrenalectomy remains the definitive procedure for cure in Cushing's disease. It is complicated by the development of Nelson's syndrome, the treatment of which remains troublesome. We report the long-term follow-up, median 17 yr (range, 8-22 yr), of 13 patients (3 males and 10 females) treated with pituitary surgery for Nelson's syndrome at a median age of 35 yr (range, 21-67 yr). The presence of a pituitary mass lesion necessitated neurosurgery in all. Preoperatively, the median plasma ACTH level was 664 pmol/liter (range, 92-3665 pmol/liter); this fell to 29 pmol/liter (range, <2 to 1124 pmol/liter) postoperatively (P < 0.0005). Cutaneous hyperpigmentation was reduced in all and resolved in 11 patients. The pituitary tumor bulk was clearly reduced in 12 patients. There was no perioperative mortality. No patient developed a visual field defect attributable to surgery. New anterior pituitary hormone deficiency occurred in seven patients, and permanent diabetes insipidus occurred in five patients. At latest follow-up, the median plasma ACTH is 73 pmol/liter (range, <2 to 7759 pmol/liter); six patients have levels of less than 44 pmol/liter and also have a resolution of their pigmentation and no evidence of a recurrence of a pituitary mass lesion. We conclude that pituitary surgery is an efficacious treatment for mass lesions associated with Nelson's syndrome, has long-term benefit with minimal side effects, and must be considered in the management of this distressing complication.

Schistosoma haematobium presenting as an intrinsic conus tumour.

In the small and diverse group of atypical, non-neoplastic intramedullary spinal cord lesions, parasitic infections are rarely considered, especially in Caucasian patients without systemic complaints or eosinophilia. A case of atypical myelopathy caused by Schistosoma haematobium is presented. The clinical, laboratory and imaging features in the MRI era both before and after treatment are discussed.

A new anterior cervical instrumentation system combining an intradiscal cage with an integrated plate: an early technical report.

STUDY DESIGN: To provide a technical report on a new device. Early outcome assessment of patients undergoing anterior cervical decompression and stabilization with the described technique. OBJECTIVES: To detail the operative and technical aspects of the new anterior cervical instrumentation and to identify its suitability for an extensive clinical study. SUMMARY OF BACKGROUND DATA: The controversy over the need for fusion in the surgery of cervical disc disease is in part fueled by the absence of an ideal technique. However, the design of the integrated anterior cervical plate and cage device (PCB) appears to provide immediate stability and to restore disc height and cervical lordosis in addition to reducing graft recipient and donor site-related complications. METHODS: After a standard anterior cervical discectomy and preparation of the disc space, the correct size of the cage with integrated plate is inserted. Self-tapping screws are inserted without image intensifier. Cancellous bone chips are used. The technique was used in 29 patients that were followed prospectively from 5 to 24 months (median 8 months, interquartile range 6-15 months). RESULTS: The technique was easy to learn and implement. The authors' experience has been free of intraoperative complications. After surgery no screw backout or device failure was identified. Twenty-seven patients improved clinically. Donor site morbidity was trivial. No collars were applied after surgery. CONCLUSIONS: The design of the system appears to prevent bone-graft recipient site and donor site complications, provides immediate biomechanical stability, prevents screw backout or breakage, and restores posterior interbody height and lordosis. The device is of sufficient promise to warrant further close evaluation focusing on long-term outcome. The new radiolucent version has potential advantages for the assessment of fusion.